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p15INK4b methylation correlates with thrombocytopenia, blast percentage, and survival in myelodysplastic syndromes in a dose dependent manner: Quantitation using pyrosequencing study

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Yoon, Jong Hyun; Lee, Dong Soon; Kim, Miyoung; Kim, Song-yee; Kim, Young Tae; Hwang, Sang Mee; Park, Hyun-Kyung; Oh, Bora; She, Cha Ja; Yoon, Sung Soo; Yang, Inchul
Issue Date
2010-06
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
LEUKEMIA RESEARCH; Vol.34 6; 718-722
Keywords
p15INK4bPrognosisMyelodysplastic syndromesMethylationPyrosequencing
Abstract
We investigated how the quantity of p15INK4b methylation related to International Prognosic Scoring System variables and survival in 74 patients with de novo myelodysplastic syndrome (MDS). Pyrosequencing of 11 consecutive CpG sites of the p15INK4b promotor region was performed, with the extent of CpG cytosine methylation assessed in terms of methylation level (MtL). Patients with >5% bone marrow blasts had higher MtL than patients with <5% blasts (10.1% vs. 6.1%, p = 0.030, respectively). Methylation was not associated with chromosomal aberrations. The MtL of patients with thrombocytopenia were higher than patients without thrombocytopenia (11.2% vs. 6.2%, p = 0.036, respectively); they were higher in patients with cytopenias in >= 2 lineages than in patients with either unilineage or no cytopenia (9.8% vs. 4.1%, p = 0.036, respectively). The survival of patients with >7% MtL was worse than patients with <7% MtL (p = 0.031). Heavy p15INK4b methylation in MDS is associated with IPSS predictors of poor prognosis and adverse survival. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
ISSN
0145-2126
Language
English
URI
https://hdl.handle.net/10371/76297
DOI
https://doi.org/10.1016/j.leukres.2009.09.007
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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