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Antituberculosis medication as a possible epigenetic factor of Leber`s hereditary optic neuropathy
DC Field | Value | Language |
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dc.contributor.author | Seo, Je Hyun | - |
dc.contributor.author | Hwang, Jeong-Min | - |
dc.contributor.author | Park, Sung Sup | - |
dc.date.accessioned | 2012-05-23T02:09:55Z | - |
dc.date.available | 2012-05-23T02:09:55Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY; Vol.38 4; 363-366 | ko_KR |
dc.identifier.issn | 1442-6404 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76308 | - |
dc.description.abstract | Purpose: To investigate if antituberculosis medication including ethambutol could be a possible epigenetic factor in visual loss in Leber`s hereditary optic neuropathy (LHON). Methods: The authors reviewed the medical records of 46 patients registered at Bundang Seoul National University Hospital from 2002 to 2006, who developed the typical clinical neuro-ophthalmologic features of LHON and possessed a mtDNA mutation at nucleotide 11778, 14484, 3460 or 4171. Results: Three of the 46 patients developed visual loss while taking antituberculosis medication. These three patients had the mtDNA 11778 mutation with a mean age of 32.7 years at the onset of visual loss, whereas the mean age of other 43 patients was 21.2 years. One of these three patients was female. Conclusion: Antituberculosis medication may be an epigenetic factor of LHON in patients with a primary LHON mutation. This risk should be recognized by physicians and LHON carriers. | ko_KR |
dc.description.sponsorship | This work was supported by the Basic Research
Program of the Korean Science & Engineering Foundation (grant no. R01-2005-000-10875-0); and a grant of the Korea Health 21 R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (A080299). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | antituberculosis medication | ko_KR |
dc.subject | Leber`s hereditary optic neuropathy | ko_KR |
dc.subject | epigenetic factor | ko_KR |
dc.title | Antituberculosis medication as a possible epigenetic factor of Leber`s hereditary optic neuropathy | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 서재현 | - |
dc.contributor.AlternativeAuthor | 황정민 | - |
dc.contributor.AlternativeAuthor | 박성섭 | - |
dc.identifier.doi | 10.1111/j.1442-9071.2010.02240.x | - |
dc.citation.journaltitle | CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.description.citedreference | Ikeda A, 2006, JPN J OPHTHALMOL, V50, P280, DOI 10.1007/s10384-005-0308-7 | - |
dc.description.citedreference | CHOWDHURY B, 2006, INDIAN J OPHTHALMOL, V54, P218 | - |
dc.description.citedreference | Sadun AA, 2003, AM J OPHTHALMOL, V136, P231, DOI 10.1016/S0002-9394(03)00099-0 | - |
dc.description.citedreference | Mackey DA, 2003, EYE, V17, P312, DOI 10.1038/sj.eye.6700362 | - |
dc.description.citedreference | Kim JY, 2003, J NEUROL, V250, P278, DOI 10.1007/s00415-003-0985-4 | - |
dc.description.citedreference | FUKAMI S, 2003, RINSHO GANKA JPN J C, V57, P427 | - |
dc.description.citedreference | Kim JY, 2002, ANN NEUROL, V51, P630, DOI 10.1002/ana.10177 | - |
dc.description.citedreference | SADUN AA, 2002, SEMIN OPHTHALMOL, V17, P29 | - |
dc.description.citedreference | Shin YJ, 2007, OPHTHALMOLOGY, V114, P1341, DOI 10.1016/j.ophtha.2006.10.030 | - |
dc.description.citedreference | Warner JEA, 2001, J NEURO-OPHTHALMOL, V21, P92 | - |
dc.description.citedreference | Shaikh S, 2001, AM J OPHTHALMOL, V131, P143 | - |
dc.description.citedreference | MARINIS MD, 2001, J NEUROL, V248, P818 | - |
dc.description.citedreference | Yoon YH, 2000, TOXICOL APPL PHARM, V162, P107 | - |
dc.description.citedreference | Dotti MT, 1998, J NEUROL, V245, P302 | - |
dc.description.citedreference | NEWMAN NJ, 1998, WALSH HOYTS CLIN NEU, P742 | - |
dc.description.tc | 1 | - |
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