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The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes

Cited 54 time in Web of Science Cited 56 time in Scopus
Authors
Kim, Min; Ahn, Byung Yong; Lee, Ji Seon; Chung, Sung Soo; Park, Sang Gyu; Lee, Hong Kyu; Park, Kyong Soo; Jung, Hye Seung; Lim, Soo
Issue Date
2009-11-06
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Vol.389 1; 70-73
Keywords
Rg3GinsenosideIRS-1Insulin signaling
Abstract
The ginsenoside Rg3 is known to have a protective effect against hyperglycemia, obesity and diabetes in vivo. In this study, we examined the effect of Rg3 on insulin signaling and glucose uptake in cultured L6 myotubes. Rg3 increased glucose uptake both in the basal and insulin-induced states of L6 myotubes. Consistent with the increase in glucose uptake, Rg3 stimulated the phosphorylation of IRS-1 and Akt. Interestingly, Rg3 dramatically increased IRS-1 protein levels, while the protein level of Akt was not affected. Rg3 regulated IRS-1 expression at the transcriptional level and also increased the level of GLUT4 mRNA. Treatment of ginsam, in which Rg3 is the major compound of ginsenosides, increased the IRS-1 protein levels in OLEFT rats. In addition, we found that this effect of Rg3 on insulin signaling was not mediated by the AMPK pathway. In conclusion, these results suggest that Rg3 improves insulin signaling and glucose uptake primarily by stimulating the expression of IRS-1 and GLUT4. (C) 2009 Elsevier Inc. All rights reserved.
ISSN
0006-291X
Language
English
URI
http://hdl.handle.net/10371/76314
DOI
https://doi.org/10.1016/j.bbrc.2009.08.088
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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