Publications
Detailed Information
Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, Sun-Wha | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.contributor.author | Lee, Hee Jeong | - |
dc.contributor.author | Oh, Se-Il | - |
dc.contributor.author | Sung, Joohon | - |
dc.contributor.author | Seo, Jeong-Sun | - |
dc.contributor.author | Kim, Jong-Il | - |
dc.contributor.author | Cho, Sung-Il | - |
dc.contributor.author | Kim, Hyung-Lae | - |
dc.date.accessioned | 2012-05-23T04:22:33Z | - |
dc.date.available | 2012-05-23T04:22:33Z | - |
dc.date.issued | 2009-11-30 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 11; 841-848 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76315 | - |
dc.description.abstract | The QTc interval is a complex quantitative trait and a strong prognostic indicator of cardiovascular mortality in general, healthy people. The aim of this study was to identify non-genetic factors and quantitative trait loci that govern the QTc interval in an isolated Mongolian population. We used multiple regression analysis to determine the relationship between the QTc interval and non-genetic factors including height, blood pressure, and the plasma lipid level. Whole genome linkage analyses were performed to reveal quantitative trait loci for the QTc interval with 349 microsatellite markers from 1,080 Mongolian subjects. Among many factors previously known for association with the QTc interval, age, sex, heart rate, QRS duration of electrocardiogram and systolic blood pressure were also found to have influence on the QTc interval. A genetic effect for the QTc interval was identified based on familial correlation with a heritability value of 0.31. In a whole genome linkage analysis, we identified the four potential linkage regions 7q31-34, 5q21, 4q28, and 2q36. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | electrocardiography | ko_KR |
dc.subject | linkage (genetics) | ko_KR |
dc.subject | regression analysis | ko_KR |
dc.subject | quantitative trait loci | ko_KR |
dc.subject | quantitative trait, heritable | ko_KR |
dc.subject | long QT syndrome | ko_KR |
dc.title | Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 임선화 | - |
dc.contributor.AlternativeAuthor | 이미경 | - |
dc.contributor.AlternativeAuthor | 이희정 | - |
dc.contributor.AlternativeAuthor | 오세일 | - |
dc.contributor.AlternativeAuthor | 김형래 | - |
dc.contributor.AlternativeAuthor | 성주혼 | - |
dc.contributor.AlternativeAuthor | 조성일 | - |
dc.contributor.AlternativeAuthor | 서정선 | - |
dc.contributor.AlternativeAuthor | 김종일 | - |
dc.identifier.doi | 10.3858/emm.2009.41.11.090 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.description.citedreference | Gombojav B, 2008, EXP MOL MED, V40, P558, DOI 10.3858/emm.2008.40.5.558 | - |
dc.description.citedreference | Shah M, 2005, CIRCULATION, V112, P2517, DOI 10.1161/CIRCULATIONAHA.104.494476 | - |
dc.description.citedreference | Benoit SR, 2005, EUR J CARDIOV PREV R, V12, P363 | - |
dc.description.citedreference | Newton-Cheh C, 2005, HEART RHYTHM, V2, P277, DOI 10.1016/j.hrthm.2004.11.009 | - |
dc.description.citedreference | Grandinetti A, 2005, CLIN BIOCHEM, V38, P116, DOI 10.1016/j.clinbiochem.2004.10.004 | - |
dc.description.citedreference | Dekker JM, 2004, J AM COLL CARDIOL, V43, P565, DOI 10.1016/j.jacc.2003.09.040 | - |
dc.description.citedreference | Crow RS, 2003, CIRCULATION, V108, P1985, DOI 10.1161/01.CIR.0000095027.28753.9D | - |
dc.description.citedreference | Mangoni AA, 2003, AGE AGEING, V32, P326 | - |
dc.description.citedreference | LIU W, 2002, HUM MUTAT, V20, P475 | - |
dc.description.citedreference | Hong Y, 2001, CLIN GENET, V59, P171 | - |
dc.description.citedreference | Bednar MM, 2001, PROG CARDIOVASC DIS, V43, P1, DOI 10.1053/pcad.2001.21469 | - |
dc.description.citedreference | Splawski I, 2000, CIRCULATION, V102, P1178 | - |
dc.description.citedreference | Carter N, 2000, J HUM HYPERTENS, V14, P389 | - |
dc.description.citedreference | Friedlander Y, 1999, CLIN GENET, V56, P200 | - |
dc.description.citedreference | Busjahn A, 1999, CIRCULATION, V99, P3161 | - |
dc.description.citedreference | de Bruyne MC, 1999, EUR HEART J, V20, P278 | - |
dc.description.citedreference | Almasy L, 1998, AM J HUM GENET, V62, P1198 | - |
dc.description.citedreference | Vitelli LL, 1998, AM J CARDIOL, V81, P453 | - |
dc.description.citedreference | RUSSELL MW, 1998, J ELECTROCARDIOLOG S, V30, P64 | - |
dc.description.citedreference | Heath SC, 1997, AM J HUM GENET, V61, P748 | - |
dc.description.citedreference | Reardon M, 1996, CLIN CARDIOL, V19, P949 | - |
dc.description.citedreference | Siscovick DS, 1996, CIRCULATION, V94, P1329 | - |
dc.description.citedreference | SCHOTT JJ, 1995, AM J HUM GENET, V57, P1114 | - |
dc.description.citedreference | WANG Q, 1995, CELL, V80, P805 | - |
dc.description.citedreference | JIANG CA, 1994, NAT GENET, V8, P141 | - |
dc.description.citedreference | DEKKER JM, 1994, CIRCULATION, V90, P779 | - |
dc.description.citedreference | GARSON A, 1993, AM J CARDIOL, V72, pB14 | - |
dc.description.citedreference | KEATING M, 1991, AM J HUM GENET, V49, P1335 | - |
dc.description.citedreference | SCHOUTEN EG, 1991, CIRCULATION, V84, P1516 | - |
dc.description.citedreference | ALGRA A, 1991, CIRCULATION, V83, P1888 | - |
dc.description.citedreference | KEATING M, 1991, SCIENCE, V252, P704 | - |
dc.description.citedreference | GOLDBERG RJ, 1991, AM J CARDIOL, V67, P55 | - |
dc.description.citedreference | PETERS RW, 1990, J CLIN EPIDEMIOL, V43, P167 | - |
dc.description.tc | 2 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.