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Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA(2)/5-LOX Pathway

Cited 20 time in Web of Science Cited 22 time in Scopus
Authors
Kang, Jung Mook; Kim, Nayoung; Kim, Bongcheol; Kim, Joo-Hyon; Park, Ji Hyun; Lee, Hye Seung; Kim, Joo Sung; Song, In Sung; Jung, Hyun Chae; Jang, In-Jin; Lee, Mi Kyoung; Lee, Bong-Yong
Issue Date
2009-12
Publisher
SPRINGER
Citation
DIGESTIVE DISEASES AND SCIENCES; Vol.54 12; 2549-2560
Keywords
Cochinchina momordicaNitric oxideCalcitonin gene-related peptideGastroprotection
Abstract
Cochinchina momordica seed extract (SK-MS10), which is composed of the major compounds momordica saponins, has been evaluated for its gastroprotective effects in rat models of acute gastric mucosal damage. Ethanol and water immersion restraint stress (WRS) induced gastric damage, including hemorrhages and edema, was significantly attenuated by pretreatment with SK-MS10. In addition, SK-MS10 reduced increases of mucosal myeloperoxidase (MPO), IL-1 beta, and TNF alpha levels and the expression of cPLA(2), and 5-LOX induced by ethanol or WRS. SK-MS10 also increased hexosamine, adherent mucus, and the expression of MUC5AC. Furthermore, SK-MS10 enhanced the mucosal expression of the CGRP gene and its serum levels. N (G)-methyl L-arginine (L-NMMA) or capsaicin desensitization reversed the SK-MS10-induced gastroprotection effect. These results suggest that SK-MS10 is a gastroprotective agent against acute gastric mucosal damage by suppressing proinflammatory cytokines, down-regulating cPLA2, 5-LOX, and increasing the synthesis of mucus. Furthermore, CGRP-NO pathway was found to play an important role in these gastroprotective effects of SK-MS10.
ISSN
0163-2116
Language
English
URI
https://hdl.handle.net/10371/76320
DOI
https://doi.org/10.1007/s10620-008-0671-6
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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