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The Role of Whole-Body FDG PET/CT, Tc 99m MDP Bone Scintigraphy, and Serum Alkaline Phosphatase in Detecting Bone Metastasis in Patients with Newly Diagnosed Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Min, Joo-Won | - |
dc.contributor.author | Um, Sang-Won | - |
dc.contributor.author | Yim, Jae-Jun | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.date.accessioned | 2012-05-23T06:55:44Z | - |
dc.date.available | 2012-05-23T06:55:44Z | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 2; 275-280 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76334 | - |
dc.description.abstract | Bone scan (BS) and serum alkaline phosphatase (ALP) concentration are used to detect bone metastasis in malignancy, although whole-body fluoro-D-glucose positron emission tomography computed tomography (FDG PET/CT) is being used increasingly. But BS is still used for the detection of metastatic bone lesion. So we compared the usefulness of PET/CT, BS, and serum ALP in detecting bone metastases in patients with newly diagnosed lung cancer. The medical record database was queried to identify all patients with a new diagnosis of lung cancer between January 2004 and December 2005, who had a PET/CT, BS, and serum ALP before treatment. We retrospectively reviewed all patients` records and radiological reports. One hundred eighty-two patients met the inclusion criteria. Bone metastases were confirmed in 30 patients. The sensitivity values were 93.3% for PET/CT, 93.3% for BS, 26.7% for serum ALP concentration, and 26.7% for BS complemented with serum ALP concentration. The respective specificity values were 94.1%, 44.1%, 94.1%, and 97.3%. The kappa statistic suggested a poor agreement among the three modalities. FDG PET/CT and BS had similar sensitivity, but PET/CT had better specificity and accuracy than BS. PET/CT is more useful than BS for evaluating bone metastasis. However, in the advanced stage, because of its high specificity, BS complemented with serum ALP is a cost-effective modality to avoid having to use PET/CT. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Lung Neoplasms | ko_KR |
dc.subject | Alkaline Phosphatase | ko_KR |
dc.subject | Bone Scan | ko_KR |
dc.subject | Bone Metastasis | ko_KR |
dc.subject | Fluorodeoxyglucose F18 | ko_KR |
dc.subject | PET/CT | ko_KR |
dc.title | The Role of Whole-Body FDG PET/CT, Tc 99m MDP Bone Scintigraphy, and Serum Alkaline Phosphatase in Detecting Bone Metastasis in Patients with Newly Diagnosed Lung Cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 민주원 | - |
dc.contributor.AlternativeAuthor | 엄상원 | - |
dc.contributor.AlternativeAuthor | 임재준 | - |
dc.contributor.AlternativeAuthor | 유철규 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 심영수 | - |
dc.contributor.AlternativeAuthor | 김영환 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.2.275 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
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dc.description.tc | 10 | - |
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