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Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans

Cited 13 time in Web of Science Cited 15 time in Scopus
Authors
Kim, Jin Taek; Kim, Yeonjung; Cho, Young Min; Koo, Bo Kyung; Shin, Hyoung Doo; Choi, Jung Won; Park, Kyong Soo; Oh, Bermseok; Jang, Hak Chul; Lee, Eun Kyung
Issue Date
2009-01
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
CLINICAL ENDOCRINOLOGY; Vol.70 1; 66-74
Abstract
Adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) are considered as candidate genes for type 2 diabetes because they mediate the metabolic effects of adiponectin on target tissues. We investigated whether common polymorphisms of ADIPOR1 and ADIPOR2 are associated with type 2 diabetes or its related phenotypes in Koreans. By sequencing of the DNA samples from 24 unrelated Korean subjects, we selected seven single nucleotide polymorphisms (SNPs) from ADIPOR1 and four SNPs from ADIPOR2 for genotyping in 757 type 2 diabetic patients and 644 nondiabetic subjects. None of the SNPs were associated with the risk of type 2 diabetes. However, g.-7309A > G (rs75172865) in ADIPOR1 was associated with lower insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Thereafter, we transfected three different human cell lines with plasmids harbouring g.-7309A > G and found that this variant reduced the promoter activity of ADIPOR1. In ADIPOR2, g.-63442G (novel SNP) and g.33447T (rs1044471) were associated with smaller waist circumference. None of the SNPs in either ADIPOR1 or ADIPOR2 were associated with the risk of type 2 diabetes in Koreans. However, the altered activity of the ADIPOR1 promoter was associated with insulin resistance and SNPs of ADIPOR2 were associated with waist circumference.
ISSN
0300-0664
Language
English
URI
http://hdl.handle.net/10371/76338
DOI
https://doi.org/10.1111/j.1365-2265.2008.03296.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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