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Impact of resistance to first-line and injectable drugs on treatment outcomes in MDR-TB

Cited 20 time in Web of Science Cited 22 time in Scopus
Authors
Hwang, S. S.; Kim, H-R.; Kim, H. J.; Kim, M. J.; Yoo, C-G.; Han, S. K.; Yim, J-J.; Shim, Y-S.; Kim, Y. W.; Lee, S. M.
Issue Date
2009-03
Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
Citation
EUROPEAN RESPIRATORY JOURNAL; Vol.33 3; 581-585
Keywords
Extensive drug resistancestreptomycintuberculosismultidrug resistance
Abstract
Recently, resistance to additional first-line and injectable drugs was reported to be an independent risk factor for adverse outcomes in multidrug-resistant (MDR) tuberculosis (TB) patients. The aim of the present study was to confirm these observations in MDR-TB patients without Hill infection. MDR-TB patients treated at a tertiary referral hospital in South Korea between January 1996 and December 2005 were included. The unadjusted and adjusted odds ratios of adverse treatment outcome were calculated for resistance to each drug and combination of drugs using simple or multiple logistic regressions. None of the resistance to additional first-line or injectable drugs was associated with higher odds for adverse treatment outcome in 155 MDR but nonextensively drug-resistant (non-XDR) TB patients. However, streptomycin resistance was associated with 12 times the odds for adverse treatment outcome in 42 extensively drug-resistant (XDR) TB patients. Neither combinations of first-line drugs nor those of injectable drugs were associated with increased odds for adverse treatment outcomes in non-XDR MDR-TB patients or XDR-TB patients. Only streptomycin resistance among the first-line or injectable drugs was associated with adverse treatment outcomes in extensively drug-resistant tuberculosis patients without HIV infection.
ISSN
0903-1936
Language
English
URI
http://hdl.handle.net/10371/76347
DOI
https://doi.org/10.1183/09031936.00099608
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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