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The Heme Oxygenase-1 Genotype is a Risk Factor to Renal Impairment of IgA Nephropathy at Diagnosis, Which is a Strong Predictor of Mortality
DC Field | Value | Language |
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dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Cho, Hyun Jin | - |
dc.contributor.author | Lee, Tae Woo | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Jeon, Un Sil | - |
dc.contributor.author | Park, Jong-Won | - |
dc.contributor.author | Shin, Young-Tai | - |
dc.contributor.author | Na, Ki-Ryang | - |
dc.contributor.author | Kang, Young Sun | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.contributor.author | Lee, Kang Wook | - |
dc.contributor.author | Yoon, Kyung-Woo | - |
dc.contributor.author | Do, Jun-Young | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Yoon, Hyung Jin | - |
dc.date.accessioned | 2012-05-23T08:56:04Z | - |
dc.date.available | 2012-05-23T08:56:04Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 ; S30-S37 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76355 | - |
dc.description.abstract | The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, UM, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, UM, or UL genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, UM, or UL genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Heme Oxygenase | ko_KR |
dc.subject | Glomerulonephritis | ko_KR |
dc.subject | IGA | ko_KR |
dc.subject | Renal Insufficiency | ko_KR |
dc.title | The Heme Oxygenase-1 Genotype is a Risk Factor to Renal Impairment of IgA Nephropathy at Diagnosis, Which is a Strong Predictor of Mortality | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 진호준 | - |
dc.contributor.AlternativeAuthor | 조현진 | - |
dc.contributor.AlternativeAuthor | 이태우 | - |
dc.contributor.AlternativeAuthor | 나기영 | - |
dc.contributor.AlternativeAuthor | 윤형진 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.contributor.AlternativeAuthor | 김성권 | - |
dc.contributor.AlternativeAuthor | 전은실 | - |
dc.contributor.AlternativeAuthor | 도준영 | - |
dc.contributor.AlternativeAuthor | 박종원 | - |
dc.contributor.AlternativeAuthor | 윤경우 | - |
dc.contributor.AlternativeAuthor | 신영태 | - |
dc.contributor.AlternativeAuthor | 이강욱 | - |
dc.contributor.AlternativeAuthor | 나기량 | - |
dc.contributor.AlternativeAuthor | 차대룡 | - |
dc.contributor.AlternativeAuthor | 강영선 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.S1.S30 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.description.citedreference | Courtney AE, 2008, AM J KIDNEY DIS, V51, P678, DOI 10.1053/j.ajkd.2007.11.033 | - |
dc.description.citedreference | Courtney AE, 2008, NEPHROL DIAL TRANSPL, V23, P608, DOI 10.1093/ndt/gfm736 | - |
dc.description.citedreference | Hong JS, 2007, MATURITAS, V56, P411, DOI 10.1016/j.maturitas.2006.11.004 | - |
dc.description.citedreference | Zampino M, 2006, AM J PHYSIOL-HEART C, V291, pH957, DOI 10.1152/ajpheart.00580.2005 | - |
dc.description.citedreference | Wijpkema JS, 2006, PHARMACOGENET GENOM, V16, P331 | - |
dc.description.citedreference | Barratt J, 2005, J AM SOC NEPHROL, V16, P2088 | - |
dc.description.citedreference | Levey AS, 2005, KIDNEY INT, V67, P2089 | - |
dc.description.citedreference | Kikuchi A, 2005, HUM GENET, V116, P354, DOI 10.1007/s00439-004-1162-2 | - |
dc.description.citedreference | Descamps-Latscha B, 2004, KIDNEY INT, V66, P1606 | - |
dc.description.citedreference | Baan C, 2004, AM J TRANSPLANT, V4, P811, DOI 10.1111/j.1600-6143.2004.00420.x | - |
dc.description.citedreference | Exner M, 2004, TRANSPLANTATION, V77, P538, DOI 10.1097/01.TP.0000113467.36269.F8 | - |
dc.description.citedreference | Gonzalez-Michaca L, 2004, AM J PHYSIOL-RENAL, V286, pF370, DOI 10.1152/ajprenal.00300.2003 | - |
dc.description.citedreference | Funk M, 2004, THROMB RES, V113, P217, DOI 10.1016/j.thromres.2004.03.003 | - |
dc.description.citedreference | Toth B, 2003, ARCH SURG-CHICAGO, V138, P1375 | - |
dc.description.citedreference | Hirai H, 2003, BLOOD, V102, P1619, DOI 10.1182/blood-2002-12-3733 | - |
dc.description.citedreference | Kanakiriya SKR, 2003, AM J PHYSIOL-RENAL, V284, pF546, DOI 10.1152/ajprenal.00298.2002 | - |
dc.description.citedreference | Otterbein LE, 2003, NAT MED, V9, P183, DOI 10.1038/nm817 | - |
dc.description.citedreference | Kaneda H, 2002, ARTERIOSCL THROM VAS, V22, P1680, DOI 10.1161/01.ATV.0000033515.96747.6F | - |
dc.description.citedreference | Chen YH, 2002, HUM GENET, V111, P1, DOI 10.1007/s00439-002-0769-4 | - |
dc.description.citedreference | Gunther L, 2002, DIABETES, V51, P994 | - |
dc.description.citedreference | Inguaggiato P, 2001, KIDNEY INT, V60, P2181 | - |
dc.description.citedreference | Brouard S, 2000, J EXP MED, V192, P1015 | - |
dc.description.citedreference | Otterbein LE, 2000, NAT MED, V6, P422 | - |
dc.description.citedreference | Shimizu H, 2000, CRIT CARE MED, V28, P809 | - |
dc.description.citedreference | Yamada N, 2000, AM J HUM GENET, V66, P187 | - |
dc.description.citedreference | VACHHARAJANI TJ, 2000, AM J PHYSIOL-HEART C, V278, P1613 | - |
dc.description.citedreference | Datta PK, 1999, J AM SOC NEPHROL, V10, P2540 | - |
dc.description.citedreference | Yachie A, 1999, J CLIN INVEST, V103, P129 | - |
dc.description.citedreference | Woo J, 1998, TRANSPL IMMUNOL, V6, P84 | - |
dc.description.citedreference | Mosley K, 1998, KIDNEY INT, V53, P672 | - |
dc.description.citedreference | NAKAGAMI T, 1993, BIOCHIM BIOPHYS ACTA, V1158, P189 | - |
dc.description.citedreference | VERMA A, 1993, SCIENCE, V259, P381 | - |
dc.description.citedreference | MAINES MD, 1993, J PHARMACOL EXP THER, V264, P457 | - |
dc.description.citedreference | NATH KA, 1992, J CLIN INVEST, V90, P267 | - |
dc.description.citedreference | CHEN HC, 1992, J CLIN LAB ANAL, V6, P35 | - |
dc.description.citedreference | COCKCROFT DW, 1976, NEPHRON, V16, P31 | - |
dc.description.tc | 4 | - |
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