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Weight changes after adjuvant treatment in Korean women with early breast cancer

Cited 33 time in Web of Science Cited 34 time in Scopus
Authors
Han, Hye-Suk; Lee, Keun-Wook; Kim, Jee Hyun; Kim, Sung-Won; Oh, Do-Youn; Bang, Soo-Mee; Lee, Jong Seok; Im, Seock-Ah; Kim, In-Ah
Issue Date
2009-03
Publisher
SPRINGER
Citation
BREAST CANCER RESEARCH AND TREATMENT; Vol.114 1; 147-153
Keywords
Adjuvant treatmentBody mass indexWeight gainChemotherapyBreast cancer
Abstract
Background Weight gain is a common problem in breast cancer patients and is reported to be associated with poorer survival. However, most data are limited to Western women. We evaluated weight changes after adjuvant treatment in Korean women with early breast cancer. Methods The authors reviewed the records of 260 patients with stage I-III breast cancer treated between June 2003 and February 2006. Body weight, body mass index (BMI) and menopausal status at baseline and after 3, 6, 12 and 24 months of adjuvant treatment were reviewed. Results Mean patient age was 47.0 years and 61.1% of women were premenopausal. Among them, 195 patients (75.8%) received chemotherapy and 186 (71.5%) received hormonal therapy. Mean baseline weight was 57.5 +/- 9.8 kg and mean BMI was 23.5 +/- 1.6 kg/m(2) (22.8 +/- 3.0 vs. 24.7 +/- 3.2 kg/m(2) for pre- vs. post-menopausal women, P = 0.286). Mean weight changes were; 0.30 kg at 3 months (P = 0.019); 0.16 kg at 6 months (P = 0.367); -0.34 kg at 1 year (P = 0.082); -0.40 kg at 2 years (P = 0.097). Twenty-three patients (10.4%) gained more than 5% of baseline body weight at 1 year, but no clinical variable was found to be associated with these weight gains. Conclusion This study shows that Korean women with early breast cancer do not gain weight after adjuvant treatment. Further studies are needed to determine differences between Asian and Western women in terms of weight changes and prognosis in early breast cancer.
ISSN
0167-6806
Language
English
URI
http://hdl.handle.net/10371/76357
DOI
https://doi.org/10.1007/s10549-008-9984-6
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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