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Hemolytic Disease of the Newborn Associated with Anti-Jr(a) Alloimmunization in a Twin Pregnancy: The First Case Report in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyungsuk | - |
dc.contributor.author | Park, Min-Jeong | - |
dc.contributor.author | Choi, Ji Seon | - |
dc.contributor.author | Sung, Tae-Jung | - |
dc.contributor.author | Han, Kyou-Sup | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Hyun, Jungwon | - |
dc.date.accessioned | 2012-05-24T00:23:23Z | - |
dc.date.available | 2012-05-24T00:23:23Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | KOREAN JOURNAL OF LABORATORY MEDICINE; Vol.30 5; 511-515 | ko_KR |
dc.identifier.issn | 1598-6535 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76360 | - |
dc.description.abstract | Jr(a) is a high-frequency antigen found in all ethnic groups. However, the clinical significance of the anti-Jr(a) antibody has remained controversial. Most studies have reported mild hemolytic disease of the newborn and fetus (HDNF) in Jr(a)-positive patients. Recently, fatal cases of HDNF have also been reported. We report the first case of HDNF caused by anti-Jr(a) alloimmunization in twins in Korea. A 33-yr-old nulliparous woman with no history of transfusion or amniocentesis was admitted at the 32nd week of gestation because of vaginal bleeding caused by placenta previa. Anti-Jr(a) antibodies were detected in a routine laboratory examination. An emergency cesarean section was performed at the 34th week of gestation, and 2 premature infant twins were delivered. Laboratory examination showed positive direct antiglobulin test and Jr(a+) phenotype in the red blood cells and the presence of anti-Jr(a) antibodies in the serum in both neonates. The infants underwent phototherapy for neonatal jaundice; this was followed by conservative management. They showed no further complications and were discharged on the 19th postpartum day. Preparative management to ensure the availability of Jr(a-) blood, via autologous donation, and close fetal monitoring must be performed even in cases of first pregnancy in Jr(a-) women. (Korean J Lab Med 2010;30:511-5) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC LABORATORY MEDICINE | ko_KR |
dc.subject | Anti-Jr(a) | ko_KR |
dc.subject | Neonatal jaundice | ko_KR |
dc.subject | Fetal erythroblastosis | ko_KR |
dc.subject | Hematologic pregnancy complications | ko_KR |
dc.title | Hemolytic Disease of the Newborn Associated with Anti-Jr(a) Alloimmunization in a Twin Pregnancy: The First Case Report in Korea | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김형석 | - |
dc.contributor.AlternativeAuthor | 성태정 | - |
dc.contributor.AlternativeAuthor | 박경운 | - |
dc.contributor.AlternativeAuthor | 현정원 | - |
dc.contributor.AlternativeAuthor | 최지선 | - |
dc.contributor.AlternativeAuthor | 박민정 | - |
dc.contributor.AlternativeAuthor | 한규섭 | - |
dc.identifier.doi | 10.3343/kjlm.2010.30.5.511 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF LABORATORY MEDICINE | - |
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dc.description.tc | 0 | - |
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