Browse

Effective second-line chemotherapy for extranodal NK/T-cell lymphoma consisting of etoposide, ifosfamide, methotrexate, and prednisolone

Cited 30 time in Web of Science Cited 34 time in Scopus
Authors
Kim, B. -S.; Kim, D. -W.; Im, S. -A.; Kim, C. W.; Kim, T. -Y.; Yoon, S. -S.; Heo, D. S.; Bang, Yung-Jue; Park, S.; Kim, B. K.; Kim, N. K.
Issue Date
2009-01
Publisher
OXFORD UNIV PRESS
Citation
Annals of Oncology, Vol.20 No.1, pp.121-128
Keywords
NK/T-cell lymphomasalvage chemotherapysecond-line chemotherapy
Abstract
Background: Many patients with extranodal natural killer/T-cell lymphoma (NTCL) fail to the front-line therapy and need an effective second-line chemotherapy. Patients and methods: This was single-institutional, phase II study. The primary end point was response rate and secondary end points were toxicity, time to treatment failure (TTF), and overall survival (OS). Patients with relapsed or refractory NTCL were eligible. They received the chemotherapy consisting of ifosfamide, methotrexate, etoposide, and prednisolone and it was repeated every 3 weeks. Results: Thirty-two patients were enrolled and 15 patients had achieved partial remission (PR) or complete remission (CR) after the front-line chemotherapy. The International Prognostic Index scores were 0-1 in thirteen, 2 in five, 3 in five, and 4-5 in nine patients. Twelve and two patients achieved CR and PR, respectively. Median OS and TTF of all patients were 8.2 and 3.7 months, respectively. Non-hematologic toxic effects were well tolerated, but grade 3/4 leukopenia occurred in 11.7% of all cycles. Four patients developed febrile neutropenia and one patient died due to pneumonia. Conclusions: This chemotherapy regimen was moderately effective for relapsed/refractory extranodal NTCL, nasal type. Toxic effects were moderate, but caution should be exercised to prevent severe infection.
ISSN
0923-7534
Language
English
URI
https://hdl.handle.net/10371/76366
DOI
https://doi.org/10.1093/annonc/mdn551
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse