Publications

Detailed Information

Anti-allergic effects of PG102, a water-soluble extract prepared from Actinidia arguta, in a murine ovalbumin-induced asthma model

DC Field Value Language
dc.contributor.authorKim, D.-
dc.contributor.authorKim, S. H.-
dc.contributor.authorPark, E-J.-
dc.contributor.authorKang, C-Y.-
dc.contributor.authorKim, S.-
dc.contributor.authorCho, S-H.-
dc.date.accessioned2012-05-24T00:59:15Z-
dc.date.available2012-05-24T00:59:15Z-
dc.date.issued2009-02-
dc.identifier.citationCLINICAL AND EXPERIMENTAL ALLERGY; Vol.39 2; 280-289ko_KR
dc.identifier.issn0954-7894-
dc.identifier.urihttps://hdl.handle.net/10371/76371-
dc.description.abstractBackground Asthma is a chronic inflammatory disease of the lung and its incidence has been increasing around the world. We previously reported that oral administration of a water-soluble extract prepared from Actinidia arguta, code-named PG102, could modulate the level of Th1 and Th2 cytokines and suppress the production of immunoglobulin E (IgE) in the ovalbumin (OVA)-immunized murine model as well as in the in vitro cell culture system, and furthermore could significantly improve dermatitis conditions in the NC/Nga murine model. These data suggested that PG102 might have therapeutic effects in a broad range of allergic diseases. Objective To assess the possible anti-allergic effects of PG102 in the OVA-induced murine asthma model. Methods The quality of PG102 was standardized, using its effects on the production of IgE, IL-5, and IL-13, in in vitro cell culture systems. To test effects on asthma, BALB/c mice were orally administrated with PG102, followed by OVA sensitization and challenge to induce asthmatic symptoms. Airway hyperresponsiveness (AHR), bronchoalveolar lavage fluid, serum, and lung tissue were analysed by using various methods. Results PG102 could decrease the level of IgE, IL-5, and IL-13 in in vitro cell culture systems with IC(50) being 1.12-1.43 mg/mL. PG102 could ameliorate asthmatic symptoms, including AHR and eosinophilia in the lungs. Such improvement of asthmatic symptoms by PG102 was accompanied by the down-regulation of IL-5 and IgE. In PG102-treated mice, high level expression of heme oxygenase-1, a potent anti-inflammatory enzyme, was observed in alveolar inflammatory cells, while the mRNA levels of foxp3, TGF-beta 1, and IL-10, important markers for regulatory T cells, were also up-regulated in the lung tissue. Conclusions PG102 may have potential as a safe and effective reagent for the prevention or treatment of asthma.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELL PUBLISHING, INCko_KR
dc.subjectActinidia argutako_KR
dc.subjectairway hyperresponsivenessko_KR
dc.subjecteosinophiliako_KR
dc.subjectHO-1ko_KR
dc.subjectIL-5ko_KR
dc.subjectPG102ko_KR
dc.subjectIgEko_KR
dc.subjectheme oxygenase-1ko_KR
dc.subjectasthmako_KR
dc.subjectAHRko_KR
dc.titleAnti-allergic effects of PG102, a water-soluble extract prepared from Actinidia arguta, in a murine ovalbumin-induced asthma modelko_KR
dc.typeArticleko_KR
dc.identifier.doi10.1111/j.1365-2222.2008.03124.x-
dc.citation.journaltitleCLINICAL AND EXPERIMENTAL ALLERGY-
dc.description.citedreferenceKim DH, 2008, J IMMUNOL, V180, P2062-
dc.description.citedreferenceArnold E, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005989.pub2-
dc.description.citedreferenceXia ZW, 2007, AM J PATHOL, V171, P1904, DOI 10.2353/ajpath.2007.070096-
dc.description.citedreferenceLongui CA, 2007, J PEDIAT, V83, pS163, DOI 10.2223/JPED.1713-
dc.description.citedreferenceBloemen K, 2007, IMMUNOL LETT, V113, P6, DOI 10.1016/j.imlet.2007.07.010-
dc.description.citedreferenceHendeles L, 2007, ANN PHARMACOTHER, V41, P1397, DOI 10.1345/aph.1K005-
dc.description.citedreferencePark EJ, 2007, J INVEST DERMATOL, V127, P1154, DOI 10.1038/sj.jid.5700658-
dc.description.citedreferenceLee JH, 2007, CLIN CANCER RES, V13, P2584, DOI 10.1158/1078-0432.CCR-06-1785-
dc.description.citedreferenceBousquet J, 2007, ALLERGY, V62, P102, DOI 10.1111/j.1398-9995.2006.01305.x-
dc.description.citedreferenceXia ZW, 2006, J IMMUNOL, V177, P5936-
dc.description.citedreferenceBRAMAN SS, 2006, CHEST S1, V130, P4-
dc.description.citedreferencePark EJ, 2005, J ALLERGY CLIN IMMUN, V116, P1151, DOI 10.1016/j.jaci.2005.07.024-
dc.description.citedreferenceLee K, 2005, GLIA, V51, P1, DOI 10.1002/glia.20179-
dc.description.citedreferenceKeshavan P, 2005, J IMMUNOL, V174, P3709-
dc.description.citedreferenceAlmolki A, 2004, AM J PHYSIOL-LUNG C, V287, pL26, DOI 10.1152/ajplung.00237.2003-
dc.description.citedreferenceMasoli M, 2004, ALLERGY, V59, P469-
dc.description.citedreferenceZheng SG, 2004, J IMMUNOL, V172, P5213-
dc.description.citedreferenceCho JY, 2004, J CLIN INVEST, V113, P551, DOI 10.1172/JCI200419133-
dc.description.citedreferenceNakamura K, 2004, J IMMUNOL, V172, P834-
dc.description.citedreferenceAmeredes BT, 2003, AM J PHYSIOL-LUNG C, V285, pL1270, DOI 10.1152/ajplung.00145.2003-
dc.description.citedreferenceFontenot JD, 2003, NAT IMMUNOL, V4, P330, DOI 10.1038/ni904-
dc.description.citedreferenceHori S, 2003, SCIENCE, V299, P1057, DOI 10.1126/science.1079490-
dc.description.citedreferenceBaranano DE, 2002, P NATL ACAD SCI USA, V99, P16093, DOI 10.1073/pnas.252626999-
dc.description.citedreferenceChung Y, 2002, IMMUNOBIOLOGY, V206, P408-
dc.description.citedreferenceBlanc PD, 2001, CHEST, V120, P1461-
dc.description.citedreferenceChapman JT, 2001, AM J PHYSIOL-LUNG C, V281, pL209-
dc.description.citedreferenceBusse WW, 2001, NEW ENGL J MED, V344, P350-
dc.description.citedreferenceHolt PG, 2000, AM J RESP CRIT CARE, V162, pS151-
dc.description.citedreferenceChang TW, 2000, NAT BIOTECHNOL, V18, P157-
dc.description.citedreferenceHamelmann E, 1999, ALLERGY, V54, P297-
dc.description.citedreferenceMartell M, 1999, J CLIN MICROBIOL, V37, P327-
dc.description.citedreferenceWills-Karp M, 1999, ANNU REV IMMUNOL, V17, P255-
dc.description.citedreferenceChong BTY, 1998, J PHARMACOL TOXICOL, V39, P163-
dc.description.citedreferenceHamelmann E, 1997, AM J RESP CRIT CARE, V156, P766-
dc.description.citedreferenceLemanske RF, 1997, AM J RESP CRIT CARE, V156, P685-
dc.description.citedreferenceWorm M, 1997, J MOL MED-JMM, V75, P440-
dc.description.citedreferenceLOETSCHER P, 1994, FASEB J, V8, P1055-
dc.description.citedreferenceHIRANO T, 1989, J IMMUNOL METHODS, V119, P145-
dc.description.citedreferenceSTOCKER R, 1987, SCIENCE, V235, P1043-
dc.description.citedreferenceTENHUNEN R, 1969, J BIOL CHEM, V244, P6388-
dc.description.tc9-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share