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Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans
DC Field | Value | Language |
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dc.contributor.author | Park, Eun-Kyung | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Lim, Il Han | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Lee, Myung Chul | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.date.accessioned | 2012-05-24T01:19:43Z | - |
dc.date.available | 2012-05-24T01:19:43Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; Vol.36 2; 172-179 | ko_KR |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76374 | - |
dc.description.abstract | Purpose Serum Tg and I-131 WBS have been used to detect recurrent and metastatic thyroid cancers postoperatively. Tg is known to be more sensitive than I-131 WBS, and therefore, false-negative WBS cases with elevated Tg levels are frequently found. However, the clinical characteristics of false-negative Tg cases with positive WBS have not been clarified. Materials and methods The authors evaluated 824 postoperative patients with differentiated thyroid carcinoma who underwent post-ablation/therapy I-131 WBS. Tg negativity was defined as a Tg level of <= 2 ng/mL without TgAb under thyroid-stimulating hormone stimulation. Remission, recurrence, and metastasis were confirmed using pathologic or clinically findings. Results Fifty-two patients (6.3%) with functioning metastasis and negativity for TgAb were Tg-negative and posttherapy I-131 WBS-positive (TgN group), and 128 patients with functioning metastases were Tg positive and WBS positive (TgP group). The TgN group consisted of 45 cases of cervical/mediastinal lymph node metastases (86.5%) and seven cases of distant metastasis to lung or bone by follow-up WBS. The TgN group demonstrated significantly higher profiles of regional involvement than the TgP group (P<0.029). In 47 patients in the TgN group, metastatic uptake disappeared in 33, ameliorated in four, and persisted in ten during follow-up. Conclusions A significant number of differentiated thyroid cancer patients were Tg-/TgAb-negative despite a positive WBS finding. Cervical and mediastinal lymph nodes were predominant sites of metastasis in the TgN group. WBS should be undertaken routinely as a complementary modality to detect functioning recurrence and metastasis regardless of serum Tg results. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Differentiated thyroid carcinoma | ko_KR |
dc.subject | Metastasis | ko_KR |
dc.subject | Thyroglobulin | ko_KR |
dc.subject | I-131 whole body scan | ko_KR |
dc.subject | Recurrence | ko_KR |
dc.title | Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박은경 | - |
dc.contributor.AlternativeAuthor | 정준기 | - |
dc.contributor.AlternativeAuthor | 임일한 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 이명철 | - |
dc.contributor.AlternativeAuthor | 조보연 | - |
dc.identifier.doi | 10.1007/s00259-008-0912-0 | - |
dc.citation.journaltitle | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
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dc.description.tc | 19 | - |
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