Publications
Detailed Information
The effect of granulocyte-colony stimulating factor on endothelial function in patients with myocardial infarction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Y-J | - |
dc.contributor.author | Shin, J-I | - |
dc.contributor.author | Park, K-W | - |
dc.contributor.author | Lee, H-Y | - |
dc.contributor.author | Koo, B-K | - |
dc.contributor.author | Sohn, D-W | - |
dc.contributor.author | Park, Y-B | - |
dc.contributor.author | Kim, H-S | - |
dc.contributor.author | Oh, B-H | - |
dc.contributor.author | Park, B-J | - |
dc.contributor.author | Kang, H-J | - |
dc.date.accessioned | 2012-05-24T04:23:42Z | - |
dc.date.available | 2012-05-24T04:23:42Z | - |
dc.date.issued | 2009-08-15 | - |
dc.identifier.citation | HEART; Vol.95 16; 1320-1325 | ko_KR |
dc.identifier.issn | 1355-6037 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76394 | - |
dc.description.abstract | Objective: The effects of granulocyte-colony stimulating factor (G-CSF) on endothelial function are unknown. Therefore, we investigated the effects of G-CSF on endothelial function. Methods: 76 patients participating in the MAGIC-Cell-3-DES trial were enrolled. These were patients with acute myocardial infarction (AMI) or old MI (OMI) who underwent percutaneous coronary intervention (PCI), and were prospectively randomised into a G-CSF group ( G-CSF (10 mg/kg/day) injection for 3 days after PCI) or a control group. Additionally, 20 healthy volunteers were also enrolled. These subjects were categorised into five groups: AMI-control (n = 18), AMI-G-CSF (18), OMI-control (20), OMI-G-CSF (20) and healthy-G-CSF (20). Baseline flow-mediated dilation (FMD) of the brachial artery and serum inflammatory biomarkers were performed on day 1, and repeated on day 4 in all groups. GCSF was injected for 3 days between days 1 and 4 in the AMI-G-CSF, OMI-G-CSF and healthy-G-CSF groups. Results: In both the healthy-G-CSF and OMI-G-CSF groups, G-CSF increased serum high sensitivity C-reactive protein (hsCRP) (0.3 (0.5) mg/l vs 6.1 (3.5) mg/l and 5.6 (3.8) mg/l vs 13.0 (7.7) mg/l, baseline vs post-G-CSF in the healthy and OMI-G-CSF groups, respectively, p<0.001). In the AMI-G-CSF group, G-CSF hindered the decline of hsCRP during the recovery phase, resulting in a relative increase in hsCRP. However, in all three groups, G-CSF did not significantly alter FMD. Conclusion: Despite an associated increase in systemic inflammation, G-CSF treatment does not lead to acute impairment of brachial artery endothelial function in either healthy subjects or patients with MI. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | B M J PUBLISHING GROUP | ko_KR |
dc.title | The effect of granulocyte-colony stimulating factor on endothelial function in patients with myocardial infarction | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1136/hrt.2008.143966 | - |
dc.citation.journaltitle | HEART | - |
dc.description.citedreference | Park KW, 2008, J MOL CELL CARDIOL, V45, P670, DOI 10.1016/j.yjmcc.2008.07.002 | - |
dc.description.citedreference | Chang SA, 2008, HEART, V94, P995, DOI 10.1136/hrt.2007.124701 | - |
dc.description.citedreference | Black MA, 2008, HYPERTENSION, V51, P203, DOI 10.1161/HYPERTENSIONAHA.107.101014 | - |
dc.description.citedreference | Guthikonda S, 2007, ARTERIOSCL THROM VAS, V27, P1172, DOI 10.1161/ATVBAHA.106.131011 | - |
dc.description.citedreference | Ueda K, 2006, ARTERIOSCL THROM VAS, V26, pE108, DOI 10.1161/01.ATV.0000219697.99134.10 | - |
dc.description.citedreference | KANG HJ, 2006, CIRCULATION, V114, P145 | - |
dc.description.citedreference | KASTRUP J, 2006, EUR HEART J, V27, P2743 | - |
dc.description.citedreference | Hill JM, 2005, J AM COLL CARDIOL, V46, P1643, DOI 10.1016/j.jacc.2005.01.067 | - |
dc.description.citedreference | Valgimigli M, 2005, EUR HEART J, V26, P1838, DOI 10.1093/eurheartj/ehi289 | - |
dc.description.citedreference | Kang HJ, 2004, LANCET, V363, P751 | - |
dc.description.citedreference | Matsubara H, 2004, LANCET, V363, P746 | - |
dc.description.citedreference | Assmus B, 2002, CIRCULATION, V106, P3009, DOI 10.1161/01.CIR.0000043246.74879.CD | - |
dc.description.citedreference | Verma S, 2002, CIRCULATION, V106, P913, DOI 10.1161/01.CIR.0000029802.88087.5E | - |
dc.description.citedreference | Doshi SN, 2001, CLIN SCI, V101, P629 | - |
dc.description.citedreference | Carstanjen D, 2001, EXP HEMATOL, V29, P812 | - |
dc.description.citedreference | Fichtlscherer S, 2000, CIRCULATION, V102, P1000 | - |
dc.description.citedreference | Hingorani AD, 2000, CIRCULATION, V102, P994 | - |
dc.description.citedreference | Vogel RA, 2000, CLIN CARDIOL, V23, P571 | - |
dc.description.citedreference | Cavallaro AM, 2000, BONE MARROW TRANSPL, V25, P85 | - |
dc.description.citedreference | CELERMAJER DS, 1992, LANCET, V340, P1111 | - |
dc.description.citedreference | BUSSOLINO F, 1989, NATURE, V337, P471 | - |
dc.description.tc | 6 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.