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Salvage Treatment for Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Efficacy of Linezolid With or Without Carbapenem

Cited 77 time in Web of Science Cited 79 time in Scopus
Authors
Jang, Hee-Chang; Kim, Sung-Han; Kim, Kye Hyoung; Kim, Choong Jong; Song, Kyoung-Ho; Park, Wan Beom; Park, Sang-Won; Kim, Eui-Chong; Choe, Kang Won; Oh, Myoung-don; Kim, Nam Joong; Kim, Hong Bin; Jeon, Jae Hyun; Lee, Shinwon
Issue Date
2009-08-01
Publisher
UNIV CHICAGO PRESS
Citation
CLINICAL INFECTIOUS DISEASES; Vol.49 3; 395-401
Abstract
Background. Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high mortality rates, but no treatment strategy has yet been established. We performed this study to evaluate the efficacy of linezolid with or without carbapenem in salvage treatment for persistent MRSA bacteremia. Methods. All adult patients with persistent MRSA bacteremia for >= 7 days from January 2006 through March 2008 who were treated at Seoul National University Hospital were studied. The results of linezolid salvage therapy with or without carbapenem were compared with those of salvage therapy with vancomycin plus aminoglycosides or rifampicin. Results. Thirty-five patients with persistent MRSA bacteremia were studied. The early microbiological response (ie, negative results for follow-up blood culture within 72 hours) was significantly higher in the linezolid-based salvage therapy group than the comparison group (75% vs 17%; P = .006). Adding aminoglycosides or rifampicin to vancomycin was not successful in treating any of the patients, whereas linezolid-based therapy gave an 88% salvage success rate (P < .001). The S. aureus-related mortality rate was lower for patients treated with a linezolid salvage regimen than for patients continually treated with a vancomycin-based regimen (13% vs 53%; P = .030). Conclusions. Linezolid-based salvage therapy effectively eradicated S. aureus from the blood for patients with persistent MRSA bacteremia. The salvage success rate was higher for linezolid therapy than for vancomycin-based combination therapy.
ISSN
1058-4838
Language
English
URI
https://hdl.handle.net/10371/76403
DOI
https://doi.org/10.1086/600295
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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