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Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough

Cited 10 time in Web of Science Cited 11 time in Scopus
Authors
Kim, T. -B.; Oh, S. -Y.; Park, H. -K.; Jeon, S. -G.; Lee, K. -Y.; Chae, I. -H.; Cho, S. -H.; Min, K. -U.; Kim, Y. -Y.; Moon, H. -B.; Kim, Y. -K.; Cho, Y. S.; Chang, Y-S.
Issue Date
2009-08
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS; Vol.34 4; 457-464
Keywords
angiotensin-converting enzyme inhibitorsgenetic polymorphismsingle nucleotide polymorphismneurokinin-2 receptorscough
Abstract
Background and objective: Treatment with angiotensin-converting enzyme (ACE) inhibitors can induce chronic cough in many patients. Genetic variations in the neurokinin 2 receptor gene (NK2R) are significantly associated with cough sensitivity to capsaicin. Methods: This study assessed the relationship between genetic polymorphisms in the NK2R gene and chronic cough in 91 patients taking ACE inhibitors. Patients included in the study did not have chest abnormalities, postnasal drip, gastroesophageal reflux or a recent history of upper respiratory infection. Results: We detected two single nucleotide polymorphisms in the NK2R gene (i.e., Gly231Glu and Arg375His). The allelic frequencies at amino acid 231 were 36 center dot 3% for Gly/Gly, 49 center dot 5% for Gly/Glu and 14 center dot 3% for Glu/Glu. The allelic frequencies at amino acid 375 were 74 center dot 7% for Arg/Arg, 24 center dot 2% for Arg/His and 1 center dot 1% for His/His. The prevalence of chronic cough in patients with the amino acid 231 genotype was 33 center dot 3% in Gly/Gly homozygotes, 24 center dot 4% in Gly/Glu heterozygotes and 0% in Glu/Glu homozygotes. There was a statistically significant association between chronic cough and the Glu/Glu allele (P = 0 center dot 028) when the data were analyzed with a recessive model. In addition, there was a significant inverse linear association between the number of Glu231 alleles and ACE inhibitor-related cough (P = 0 center dot 026). The prevalence of chronic cough in patients with the amino acid 375 genotype was 22 center dot 1% in Arg/Arg homozygotes, 31 center dot 8% in Arg/His heterozygotes and 0% in His/His homozygotes, although none of these association were statistically significant. Conclusion: Our findings indicate that the Gly231Glu polymorphism is associated with a lower prevalence of ACE inhibitor-related cough.
ISSN
0269-4727
Language
English
URI
http://hdl.handle.net/10371/76406
DOI
https://doi.org/10.1111/j.1365-2710.2008.01018.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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