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The Relation Between Non-Alcoholic Fatty Liver Disease and the Risk of Coronary Heart Disease in Koreans

Cited 81 time in Web of Science Cited 81 time in Scopus
Authors
Choi, Su-Yeon; Kim, Donghee; Kim, Hwa Jung; Kang, Jin Hwa; Park, Min Jung; Kim, Chung Hyun; Kim, Won; Yoon, Jung-Hwan; Cho, Sang-Heon; Oh, Byung-Hee; Sung, Myung-Whun; Lee, Hyo-Suk; Kim, Yoon Jun; Choi, Seung Ho; Kim, Young Sun; Chung, Su Jin
Issue Date
2009-08
Publisher
NATURE PUBLISHING GROUP
Citation
AMERICAN JOURNAL OF GASTROENTEROLOGY; Vol.104 8; 1953-1960
Abstract
OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is known to be related to factors that predict the development of coronary heart disease (CHD), such as dyslipidemia, central obesity, and metabolic syndrome (MS). The aim of this study was to determine whether individuals with NAFLD have an elevated risk of CHD, as estimated using the Framingham risk score (FRS). METHODS: A total of 21,130 individuals who underwent a voluntary general health examination were recruited. NAFLD was diagnosed among these individuals on the basis of typical sonographic findings and a level of alcohol consumption of <20 g/day. Of the 21,130 individuals, 3,780 were excluded because they had known causes of liver disease (1,690 were alcoholics, 975 had hepatitis B virus, 242 had hepatitis C virus, 91 had other hepatitis history, and 593 were taking medication known to produce fatty liver) or a history of heart disease (189). RESULTS: NAFLD was diagnosed in 5,769 of the 17,350 individuals (33.3%). The 11,581 normal individuals constituted the control group. The 5,769 individuals with NAFLD were split into two groups on the basis of ultrasonographic findings, that is, into a mild NAFLD group (n=3,278) and a moderate-severe NAFLD group (n=2,491). Individuals with NAFLD had an elevated risk of CHD, as estimated using FRS. Multivariable regression analysis, adjusted for confounding factors, showed a strong association between a higher FRS and NAFLD. CONCLUSIONS: Individuals with ultrasonographically detected NAFLD have an elevated 10-year risk of developing CHD as estimated using FRS. Furthermore, NAFLD was found to be independently related to the risk of developing CHD, regardless of classical risk factors and other components of MS.
ISSN
0002-9270
Language
English
URI
http://hdl.handle.net/10371/76407
DOI
https://doi.org/10.1038/ajg.2009.238
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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