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Candida haemulonii and Closely Related Species at 5 University Hospitals in Korea: Identification, Antifungal Susceptibility, and Clinical Features
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-Na | - |
dc.contributor.author | Shin, Jong Hee | - |
dc.contributor.author | Sung, Heungsup | - |
dc.contributor.author | Lee, Kyungwon | - |
dc.contributor.author | Ryoo, Namhee | - |
dc.contributor.author | Jung, Sook-In | - |
dc.contributor.author | Kee, Seung Jung | - |
dc.contributor.author | Shin, Myung Geun | - |
dc.contributor.author | Ryang, Dong Wook | - |
dc.contributor.author | Suh, Soon Pal | - |
dc.contributor.author | Kim, Soo Hyun | - |
dc.contributor.author | Park, Kyung Hwa | - |
dc.contributor.author | Lee, Jin-Sol | - |
dc.contributor.author | Kim, Eui-Chong | - |
dc.date.accessioned | 2012-05-24T05:37:53Z | - |
dc.date.available | 2012-05-24T05:37:53Z | - |
dc.date.issued | 2009-03-15 | - |
dc.identifier.citation | CLINICAL INFECTIOUS DISEASES; Vol.48 6; e57-e61 | ko_KR |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76409 | - |
dc.description.abstract | Background. Candida haemulonii, a yeast species that often exhibits antifungal resistance, rarely causes human infection. During 2004-2006, unusual yeast isolates with phenotypic similarity to C. haemulonii were recovered from 23 patients (8 patients with fungemia and 15 patients with chronic otitis media) in 5 hospitals in Korea. Methods. Isolates were characterized using D1/D2 domain and ITS gene sequencing, and the susceptibility of the isolates to 6 antifungal agents was tested in vitro. Results. Gene sequencing of the blood isolates confirmed C. haemulonii group I (in 1 patient) and Candida pseudohaemulonii (in 7 patients), whereas all isolates recovered from the ear were a novel species of which C. haemulonii is its closest relative. The minimum inhibitory concentration (MIC) ranges of amphotericin B, fluconazole, itraconazole, and voriconazole for all isolates were 0.5-32 mu g/mL (MIC(50), 1 mu g/mL), 2-128 mu g/mL (MIC(50), 4 mu g/mL), 0.125-4 mu g/mL (MIC(50), 0.25 mu g/mL), and 0.03-2 mu g/mL (MIC(50), 0.06 mu g/mL), respectively. All isolates were susceptible to caspofungin (MIC, 0.125-0.25 mu g/mL) and micafungin (MIC, 0.03-0.06 mu g/mL). All cases of fungemia occurred in patients with severe underlying diseases who had central venous catheters. Three patients developed breakthrough fungemia while receiving antifungal therapy, and amphotericin B therapeutic failure, which was associated with a high MIC of amphotericin B (32 mu g/mL), was observed in 2 patients. Conclusions. Candida species that are closely related to C. haemulonii are emerging sources of infection in Korea. These species show variable patterns of susceptibility to amphotericin B and azole antifungal agents. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | UNIV CHICAGO PRESS | ko_KR |
dc.title | Candida haemulonii and Closely Related Species at 5 University Hospitals in Korea: Identification, Antifungal Susceptibility, and Clinical Features | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김미나 | - |
dc.contributor.AlternativeAuthor | 신종희 | - |
dc.contributor.AlternativeAuthor | 성흥섭 | - |
dc.contributor.AlternativeAuthor | 이경원 | - |
dc.contributor.AlternativeAuthor | 김의종 | - |
dc.contributor.AlternativeAuthor | 류남희 | - |
dc.contributor.AlternativeAuthor | 이진솔 | - |
dc.contributor.AlternativeAuthor | 정숙인 | - |
dc.contributor.AlternativeAuthor | 박경화 | - |
dc.contributor.AlternativeAuthor | 기승정 | - |
dc.contributor.AlternativeAuthor | 김수현 | - |
dc.contributor.AlternativeAuthor | 신명근 | - |
dc.contributor.AlternativeAuthor | 서순팔 | - |
dc.contributor.AlternativeAuthor | 양동욱 | - |
dc.identifier.doi | 10.1086/597108 | - |
dc.citation.journaltitle | CLINICAL INFECTIOUS DISEASES | - |
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dc.description.tc | 8 | - |
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