Browse

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective for leptomeningeal metastasis from non-small cell lung cancer patients with sensitive EGFR mutation or other predictive factors of good response for EGFR TKI

Cited 87 time in Web of Science Cited 107 time in Scopus
Authors
Yi, Hyeon Gyu; Kim, Hye Jin; Kim, Yu Jung; Han, Sae-Won; Oh, Do-Youn; Lee, Se-Hoon; Kim, Dong-Wan; Im, Seock-Ah; Kim, Tae-You; Kim, Chul Soo; Heo, Dae Seog; Bang, Yung-Jue
Issue Date
2009-07
Publisher
ELSEVIER IRELAND LTD
Citation
Lung Cancer, Vol.65 No.1, pp.80-84
Keywords
Epidermal growth factor receptorNon-small cell lung cancerLeptomeningeal metastasisSurvivalTyrosine kinase inhibitor
Abstract
The purpose of this study was to demonstrate the beneficial effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in the treatment of leptomeningeal metastasis (LM) for a select group of non-small cell lung cancer (NSCLC) patients who had a sensitive EGFR mutation or good predictive clinical factors for EGFR TKI treatment. Eleven patients with NSCLC and LM were treated with a standard dose of erlotinib (n = 9), or higher than standard dose of gefitinib followed by erlotinib (n = 2). They were treated with various therapies including whole brain radiotherapy or intrathecal chemotherapy for CNS lesion previously and concurrently with EGFR TKI. Nine of 11 patients showed overt improvement in ECOG performance status. Six patients were alive >6 months, and 2 additional patients were alive 2.5+ and 4.4+ months with clinical improvement. Two patients showed responses to higher than standard dose of gefitinib. The median overall survival was not reached. In conclusion, EGFR TKIs are effective in the treatment of LM from NSCLC when patients were selected properly. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN
0169-5002
Language
English
URI
https://hdl.handle.net/10371/76411
DOI
https://doi.org/10.1016/j.lungcan.2008.10.016
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse