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Should HLA-B*5701 Screening Be Performed in Every Ethnic Group before Starting Abacavir?

Cited 46 time in Web of Science Cited 53 time in Scopus
Authors
Park, Wan Beom; Choe, Pyoeng Gyun; Song, Kyoung-Ho; Lee, Shinwon; Jeon, Jae Hyun; Park, Myoung Hee; Choe, Kang Won; Oh, Myoung-don; Park, Sang-Won; Jang, Hee-Chang
Issue Date
2009-02-01
Publisher
UNIV CHICAGO PRESS
Citation
CLINICAL INFECTIOUS DISEASES; Vol.48 3; 365-367
Abstract
Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.
ISSN
1058-4838
Language
English
URI
https://hdl.handle.net/10371/76413
DOI
https://doi.org/10.1086/595890
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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