S-Space College of Medicine/School of Medicine (의과대학/대학원) Laboratory Medicine (검사의학전공) Journal Papers (저널논문_검사의학전공)
Should HLA-B*5701 Screening Be Performed in Every Ethnic Group before Starting Abacavir?
- Park, Wan Beom; Choe, Pyoeng Gyun; Song, Kyoung-Ho; Lee, Shinwon; Jeon, Jae Hyun; Park, Myoung Hee; Choe, Kang Won; Oh, Myoung-don; Park, Sang-Won; Jang, Hee-Chang
- Issue Date
- UNIV CHICAGO PRESS
- CLINICAL INFECTIOUS DISEASES; Vol.48 3; 365-367
- Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.