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Should HLA-B*5701 Screening Be Performed in Every Ethnic Group before Starting Abacavir?
Cited 49 time in
Web of Science
Cited 56 time in Scopus
- Authors
- Issue Date
- 2009-02-01
- Publisher
- UNIV CHICAGO PRESS
- Citation
- CLINICAL INFECTIOUS DISEASES; Vol.48 3; 365-367
- Abstract
- Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.
- ISSN
- 1058-4838
- Language
- English
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