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Prevalence of Occult Hepatitis B Virus Infection in a General Adult Population in Korea

Cited 39 time in Web of Science Cited 40 time in Scopus
Authors
Song, Eun Young; Yun, Yeo Min; Park, Myoung Hee; Seo, Dong Hee
Issue Date
2009
Publisher
KARGER
Citation
INTERVIROLOGY; Vol.52 2; 57-62
Keywords
PrevalenceHepatitis B surface antigenAnti-HBsHepatitis B virus DNAOccult hepatitis B virus infectionAnti-HBc
Abstract
Objectives: We investigated the prevalence of hepatitis B virus (HBV) markers and occult HBV infection in a general adult population in Korea. Methods: HBsAg, anti-HBs and antiHBc were analyzed on 1,091 samples of routine medical check-up examinees by chemiluminescence immunoassay. Nucleic acid amplification test (NAT) was performed on 1,047 HBsAg-negative samples by multiplex real-time polymerase chain reaction (PCR) kit for simultaneous detection of HBV, hepatitis C virus, and human immunodeficiency virus (Cobas Taqscreen MPX) in pools of six and reactive pools were resolved to individual samples, and further discriminated by PCR-based assay for HBV (Cobas Ampliscreen HBV). Results: The prevalences of HBsAg, anti-HBc, and anti-HBs were 4.0, 39.3, and 75.4%, respectively. The prevalence of anti-HBc significantly decreased with decreasing age (p < 0.001). Occult HBV infection was found in 7 (0.7%) of 1,047 HBsAg-negative subjects, and 5 of them were anti-HBc-negative. Sequencing of HBV S gene in 3 cases revealed one wild-type and two mutant strains (W74S, F85Y; T63I, W74S, T131N substitutions). Conclusions: This study helps to understand the current status of hepatitis B infection and the prevalence of occult HBV infection in a general adult population in Korea. Copyright (C) 2009 S. Karger AG, Basel
ISSN
0300-5526
Language
English
URI
https://hdl.handle.net/10371/76414
DOI
https://doi.org/10.1159/000214633
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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