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Comparison of Monthly Ibandronate Versus Weekly Risedronate in Preference, Convenience, and Bone Turnover Markers in Korean Postmenopausal Osteoporotic Women
DC Field | Value | Language |
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dc.contributor.author | Chung, Yoon-Sok | - |
dc.contributor.author | Lim, Sung-Kil | - |
dc.contributor.author | Chung, Ho-Yeon | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.contributor.author | Kim, Ghi-Su | - |
dc.contributor.author | Kang, Moo-Il | - |
dc.contributor.author | Kim, Yong-Ki | - |
dc.contributor.author | Shong, Min Ho | - |
dc.contributor.author | Byun, Dong-Won | - |
dc.contributor.author | Kwon, Nam-Hee | - |
dc.contributor.author | Lee, Yil-Seob | - |
dc.contributor.author | Shin, Chan Soo | - |
dc.contributor.author | Yoon, Hyun-Koo | - |
dc.contributor.author | Park, Ji-Hyun | - |
dc.contributor.author | Choi, Woong Hwan | - |
dc.contributor.author | Chung, Dong-Jin | - |
dc.contributor.author | Min, Yong-Ki | - |
dc.contributor.author | Park, Il-Hyung | - |
dc.date.accessioned | 2012-05-24T06:15:24Z | - |
dc.date.available | 2012-05-24T06:15:24Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | CALCIFIED TISSUE INTERNATIONAL; Vol.85 5; 389-397 | ko_KR |
dc.identifier.issn | 0171-967X | - |
dc.identifier.uri | https://hdl.handle.net/10371/76420 | - |
dc.description.abstract | Patient preferences, convenience, and bone turnover markers were evaluated for the monthly ibandronate over the weekly risedronate regimen in Korean postmenopausal osteoporotic women. This was a 6-month, prospective, randomized, open-label, multicenter study with a two-period and two-sequence crossover treatment design. After a 30-day screening period, eligible participants with postmenopausal osteoporosis were randomized to receive either monthly oral ibandronate 150 mg for 3 months followed by weekly oral risedronate 35 mg for 12 weeks (sequence A) or the same regimen in reverse order (sequence B). Patient preference and convenience were evaluated by questionnaire. The changes in serum C-telopeptide after 3 months of treatment were analyzed. A total of 365 patients were enrolled in this study (sequence A 182, sequence B 183). Of patients expressing a preference (83.4%), 74.8% preferred the monthly ibandronate regimen over the weekly regimen (25.2%). More women stated that the monthly ibandronate regimen was more convenient (84.2%) than the weekly regimen (15.8%). There was no significant difference in the change in bone turnover marker between the two treatments. The two regimens were similarly tolerable. There were fewer adverse events in the monthly ibandronate group compared to the weekly risedronate group in terms of gastrointestinal side effects (nausea and abdominal distension). This study revealed a strong preference and convenience for monthly ibandronate over weekly risedronate in Korean postmenopausal osteoporotic women. There was no significant difference in change of bone turnover marker and safety profile between the two regimens. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Ibandronate | ko_KR |
dc.subject | Korean | ko_KR |
dc.subject | Convenience | ko_KR |
dc.subject | Preference | ko_KR |
dc.subject | Risedronate | ko_KR |
dc.title | Comparison of Monthly Ibandronate Versus Weekly Risedronate in Preference, Convenience, and Bone Turnover Markers in Korean Postmenopausal Osteoporotic Women | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정윤속 | - |
dc.contributor.AlternativeAuthor | 정호연 | - |
dc.contributor.AlternativeAuthor | 이인규 | - |
dc.contributor.AlternativeAuthor | 박일형 | - |
dc.contributor.AlternativeAuthor | 김기수 | - |
dc.contributor.AlternativeAuthor | 민용기 | - |
dc.contributor.AlternativeAuthor | 강무일 | - |
dc.contributor.AlternativeAuthor | 정동진 | - |
dc.contributor.AlternativeAuthor | 김용기 | - |
dc.contributor.AlternativeAuthor | 최웅환 | - |
dc.contributor.AlternativeAuthor | 송민호 | - |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 변동원 | - |
dc.contributor.AlternativeAuthor | 윤현구 | - |
dc.contributor.AlternativeAuthor | 신찬수 | - |
dc.contributor.AlternativeAuthor | 이일섭 | - |
dc.contributor.AlternativeAuthor | 권남희 | - |
dc.contributor.AlternativeAuthor | 임성길 | - |
dc.identifier.doi | 10.1007/s00223-009-9294-y | - |
dc.citation.journaltitle | CALCIFIED TISSUE INTERNATIONAL | - |
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dc.description.tc | 0 | - |
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