Publications
Detailed Information
The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3 ` Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Yoon-Seok | - |
dc.contributor.author | Kim, Yoon-Keun | - |
dc.contributor.author | Kwon, Hyouk-Soo | - |
dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Kim, You-Young | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.date.accessioned | 2012-05-24T07:17:19Z | - |
dc.date.available | 2012-05-24T07:17:19Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 5; 860-866 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76437 | - |
dc.description.abstract | CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3` hexameric deoxyriboguanosine-run (3` dG(6)-run) conjugation to PE CpG-ODN has been reported to enhance immunostimulation and to protect against asthma when injected at the time of sensitization in mice. We evaluated the treatment effects of PE and PS CpG-ODN with or without 3` dG(6)-run on asthma in pre-sensitized mice. BALB/c mice sensitized with ovalbumin and alum were challenged with 1% ovalbumin on three days. CpG-ODNs (100 mu g) or PBS were injected 4 times; 27 hr before challenge and 3 hr before each challenge (CpG-dG(6:) CpG-ODN with 3` dG(6)-run, PE*-CpG-dG(6): PE-CpG-dG(6) with two PS backbones at the 5` terminus). PE-CpG showed no treatment effect. PE-CpG-dG(6) only increased ovalbumin-specific IgG2a. PE*-CpG-dG(6) increased ovalbumin-specific IgG2a but also reduced BAL fluid eosinophils and airway hyperresponsiveness. PS-CpG increased ovalbumin-specific IgG2a, reduced airway inflammation and airway hyperresponsiveness. PS-CpG-dG(6) was less effective than PS-CpG on airway inflammation and airway hyperresponsiveness. In pre-sensitized mice, PE-CpG required not only 3` dG(6)-run but also the modification of two PS linkages at 5` terminus to inhibit features of asthma. PS-CpG was strong enough to inhibit asthma but PS-CpG-dG(6) was less effective. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Asthma | ko_KR |
dc.subject | Poly G | ko_KR |
dc.subject | CpG-ODN | ko_KR |
dc.subject | Models | ko_KR |
dc.subject | Allergy | ko_KR |
dc.subject | Immunotherapy | ko_KR |
dc.subject | Animal | ko_KR |
dc.title | The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3 ` Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장윤석 | - |
dc.contributor.AlternativeAuthor | 김윤근 | - |
dc.contributor.AlternativeAuthor | 권혁수 | - |
dc.contributor.AlternativeAuthor | 박흥우 | - |
dc.contributor.AlternativeAuthor | 민경업 | - |
dc.contributor.AlternativeAuthor | 김유영 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.5.860 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.description.citedreference | Peter M, 2008, IMMUNOLOGY, V123, P118, DOI 10.1111/j.1365-2567.2007.02718.x | - |
dc.description.citedreference | Jeon SG, 2007, J ALLERGY CLIN IMMUN, V119, P831, DOI 10.1016/j.jaci.2006.12.653 | - |
dc.description.citedreference | KLINE JN, 2007, P AM THORAC SOC, V4, P283 | - |
dc.description.citedreference | Creticos PS, 2006, NEW ENGL J MED, V355, P1445, DOI 10.1056/NEJMoa052916 | - |
dc.description.citedreference | Cockcroft DW, 2006, J ALLERGY CLIN IMMUN, V118, P551, DOI 10.1016/j.jaci.2006.07.012 | - |
dc.description.citedreference | Chang YS, 2005, J ALLERGY CLIN IMMUN, V116, P1388, DOI 10.1016/j.jaci.2005.09.022 | - |
dc.description.citedreference | Vollmer J, 2005, EXPERT OPIN BIOL TH, V5, P673, DOI 10.1517/14712598.5.5.673 | - |
dc.description.citedreference | Lenert P, 2005, CLIN EXP IMMUNOL, V140, P1, DOI 10.1111/j.1365-2249.2005.02728.x | - |
dc.description.citedreference | CHANG YS, 2005, KOREAN J INTERN MED, V20, P152 | - |
dc.description.citedreference | Storni T, 2004, J IMMUNOL, V172, P1777 | - |
dc.description.citedreference | Chang YS, 2004, J KOREAN MED SCI, V19, P69 | - |
dc.description.citedreference | Lenert P, 2003, DNA CELL BIOL, V22, P621 | - |
dc.description.citedreference | Dalpke AH, 2002, IMMUNOLOGY, V106, P102 | - |
dc.description.citedreference | Park Y, 2001, J ALLERGY CLIN IMMUN, V108, P570 | - |
dc.description.citedreference | Leong KP, 2001, ANN ALLERG ASTHMA IM, V87, P96 | - |
dc.description.citedreference | Fiscus LC, 2001, J ALLERGY CLIN IMMUN, V107, P1019, DOI 10.1067/mai.2001.114703 | - |
dc.description.citedreference | Krieg AM, 2000, IMMUNOL TODAY, V21, P521 | - |
dc.description.citedreference | Lee SW, 2000, J IMMUNOL, V165, P3631 | - |
dc.description.citedreference | Ballas ZK, 1996, J IMMUNOL, V157, P1840 | - |
dc.description.citedreference | Bishop JS, 1996, J BIOL CHEM, V271, P5698 | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.