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Subclinical Hypothyroidism Might Increase the Risk of Transient Atrial Fibrillation After Coronary Artery Bypass Grafting

Cited 26 time in Web of Science Cited 35 time in Scopus
Authors
Park, Young Joo; Yoon, Ji Won; Kim, Kwang Il; Lee, You Jin; Choi, Sung Hee; Choi, Dong Ju; Choh, Joong Haeng; Kim, Seong Yeon; Lim, Cheong; Cho, Bo Youn; Jang, Hak Chul; Park, Kay-Hyun; Lim, Soo; Kim, Kyung Won
Issue Date
2009-06
Publisher
ELSEVIER SCIENCE INC
Citation
ANNALS OF THORACIC SURGERY; Vol.87 6; 1846-1852
Abstract
Background. Some studies have proposed that subclinical hypothyroidism (SCH) has adverse effects on the cardiovascular system, but little is known about the effect on patients undergoing cardiovascular operations. We examined the influence of preoperative SCH on postoperative outcome in patients undergoing coronary artery bypass grafting (CABG). Methods. Among patients who underwent CABG between July 2005 and June 2007 at Seoul National University Bundang Hospital, 224 with normal thyroid function and 36 with SCH were enrolled. Preoperative risks and postoperative outcomes were evaluated prospectively without thyroid hormone replacement. Results. There were no significant differences in primary outcomes (major adverse cardiovascular events) and secondary outcomes such as wound problems, mediastinitis, leg infection, respiratory complications, delirium, or reoperation during the same hospitalization. However, patients with SCH had a higher incidence of postoperative atrial fibrillation than those with normal thyroid function after adjustment for age, gender, body mass index, and other independent variables such as emergency operation, the use of cardiopulmonary bypass, combined valvular operation, preoperative creatinine levels, left ventricular systolic dysfunction, and nonuse of beta-blockers (45.5% vs 29%; odds ratio, 2.552; 95% confidence interval, 1.117 to 5.830; p = 0.026). Conclusions. SCH appears to influence the postoperative outcome for patients by increasing the development of postoperative atrial fibrillation. However, it is still unproven whether preoperative thyroxine replacement therapy for patients with SCH might prevent postoperative atrial fibrillation after CABG. (Ann Thorac Surg 2009; 87: 1846-52) (C) 2009 by The Society of Thoracic Surgeons
ISSN
0003-4975
Language
English
URI
http://hdl.handle.net/10371/76445
DOI
https://doi.org/10.1016/j.athoracsur.2009.03.032
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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