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Improved Outcome of Adult Recipients with a High Model for End-Stage Liver Disease Score and a Small-For-Size Graft
DC Field | Value | Language |
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dc.contributor.author | Yi, Nam-Joon | - |
dc.contributor.author | Suh, Kyung-Suk | - |
dc.contributor.author | Lee, Hae Won | - |
dc.contributor.author | Shin, Woo Young | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Lee, Kuhn Uk | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Kim, Juhyun | - |
dc.date.accessioned | 2012-05-25T01:10:20Z | - |
dc.date.available | 2012-05-25T01:10:20Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | LIVER TRANSPLANTATION; Vol.15 5; 496-503 | ko_KR |
dc.identifier.issn | 1527-6465 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76448 | - |
dc.description.abstract | Although adult-to-adult living donor liver transplantation (ALDLT) has shown comparable outcomes to deceased donor liver transplantation, the outcome of patients with a high MELD score (>25) and a small-for-size graft (SFSG<0.8% of graft-to-recipient weight ratio) is not known. For 7 years, 167 consecutive hepatitis B virus-infected recipients underwent ALDLT at our institution. Based on their MELD score without additional score for hepatocellular carcinoma (HCC), the recipients were divided into Group L (low MELD score, n = 105) or Group H (high MELD score, n = 62). To analyze the risk of the graft size, the patients were further stratified as follows: Group Hs (high MELD score and SFSG, n = 11), Hn (high MELD score and normal size graft, In 51), Ls (low MELD score and SFSG, In 18), and Ln (low MELD score and normal size graft, n = 87). The primary endpoint was one-year patient survival rate (1-YSR). The mean follow-up period was 32.6 months. The mean MELD scores were 17.1 in Group L and 32.6 in Group H. Group H had more patients with the complications of cirrhosis but less patients with HCC than Group L (p < 0.05). However, major morbidity rates and 1-YSR were similar in comparisons between Group L (46.7% and 86.7%) and H (59.7% and 83.8%) (p > 0.05). 1-YSR was similar among Group Hs (72.7%), Hn (86.3%), Ls (83.3%), and Ln (88.5%) groups (p = 0.278). The multivariate analysis revealed accompanying HCC and the year of transplant were risk factors for poor 1-YSR. However, 1-YSR without HCC patients was also similar in comparisons between group L (90.2%) and H (91.7%) (p = 0.847), and among Group Hs (80.0%), Hn (94.7%), Ls (72.7%), and Ln (96.7%) (p = 0.072). In conclusion, high MELD score (>25) didn`t predict 1-YSR in ALDLT. Improvement of the 1-YSR might be affected by center`s experience as well as the selection of patients with low risk of recurrence of HCC. Liver Transpl 15:496-503, 2009. (C) 2009 AASLD. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | JOHN WILEY & SONS INC | ko_KR |
dc.title | Improved Outcome of Adult Recipients with a High Model for End-Stage Liver Disease Score and a Small-For-Size Graft | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이남준 | - |
dc.contributor.AlternativeAuthor | 서경석 | - |
dc.contributor.AlternativeAuthor | 이해원 | - |
dc.contributor.AlternativeAuthor | 신우영 | - |
dc.contributor.AlternativeAuthor | 김주현 | - |
dc.contributor.AlternativeAuthor | 김원 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 이건욱 | - |
dc.identifier.doi | 10.1002/lt.21606 | - |
dc.citation.journaltitle | LIVER TRANSPLANTATION | - |
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dc.description.tc | 16 | - |
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