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Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet`s disease susceptibility loci

Cited 401 time in Web of Science Cited 431 time in Scopus
Issue Date
2010-08
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE GENETICS; Vol.42 8; 703-U83
Abstract
Behçets disease is a chronic systemic inflammatory disorder
characterized by four major manifestations: recurrent
ocular symptoms, oral and genital ulcers and skin lesions1.
We conducted a genome-wide association study in a Japanese
cohort including 612 individuals with Behçets disease and
740 unaffected individuals (controls). We identified two
suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2,
rs12119179, P = 2.7 × 10−8) and 1q32.1 (IL10, rs1554286,
P = 8.0 × 10−8). A meta-analysis of these two loci with results
from additional Turkish and Korean cohorts showed genomewide
significant associations (rs1495965 in IL23R-IL12RB2,
P = 1.9 × 10−11, odds ratio = 1.35; rs1800871 in IL10, P = 1.0 ×
10−14, odds ratio = 1.45).
ISSN
1061-4036
Language
English
URI
https://hdl.handle.net/10371/76466
DOI
https://doi.org/10.1038/ng.624
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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