S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet`s disease susceptibility loci
- Mizuki, Nobuhisa ; Meguro, Akira ; Ota, Masao ; Ohno, Shigeaki ; Kawagoe, Tatsukata ; Kera, Jiro ; Yatsu, Keisuke ; Lee, Eun-Bong ; Namba, Kenichi ; Inoko, Hidetoshi ; Ishigatsubo, Yoshiaki ; Bahram, Seiamak ; Mochizuki, Manabu ; Sugita, Sunao ; Takeno, Mitsuhiro ; Horie, Yukihiro ; Kitaichi, Nobuyoshi ; Song, Yeong-Wook ; Okada, Eiichi ; Ito, Norihiko ; Shiota, Tomoko
- Issue Date
- NATURE PUBLISHING GROUP
- NATURE GENETICS; Vol.42 8; 703-U83
- Behçets disease is a chronic systemic inflammatory disorder
characterized by four major manifestations: recurrent
ocular symptoms, oral and genital ulcers and skin lesions1.
We conducted a genome-wide association study in a Japanese
cohort including 612 individuals with Behçets disease and
740 unaffected individuals (controls). We identified two
suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2,
rs12119179, P = 2.7 × 10−8) and 1q32.1 (IL10, rs1554286,
P = 8.0 × 10−8). A meta-analysis of these two loci with results
from additional Turkish and Korean cohorts showed genomewide
significant associations (rs1495965 in IL23R-IL12RB2,
P = 1.9 × 10−11, odds ratio = 1.35; rs1800871 in IL10, P = 1.0 ×
10−14, odds ratio = 1.45).
- Files in This Item: There are no files associated with this item.