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Emphysema as a Risk Factor for the Outcome of Surgical Resection of Lung Cancer

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Lee, Sung Ah; Sun, Joo Sung; Park, Joo Hun; Park, Kyung Joo; Choi, Ho; Chung, Woo Young; Park, Kwang Joo; Hwang, Sung Chul; Lee, Keu Sung; Sheen, Seung Soo; Lee, Sung Soo
Issue Date
2010-08
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 8; 1146-1151
Keywords
Non-Small-Cell Lung CarcinomaEmphysemaSurgery
Abstract
It is unclear whether emphysema, regardless of airflow limitation, is a predictive factor associated with survival after lung cancer resection. Therefore, we investigated whether emphysema was a risk factor associated with the outcome after resection for lung cancer. This study enrolled 237 patients with non small cell lung cancer with stage I or II who had surgical removal. Patient outcome was analyzed based on emphysema. Emphysema was found in 43.4% of all patients. Patients with emphysema were predominantly men and smokers, and had a lower body mass index than the patients without emphysema. The patients without emphysema (n=133) survived longer (mean 51.2 +/- 3.0 vs. 40.6 +/- 3.1 months, P=0.042) than those with emphysema (n=104). The univariate analysis showed a younger age, higher FEV(1)/FVC, higher body mass index, cancer stage I, and a lower emphysema score were significant predictors of better survival. The multivariate analysis revealed a younger age, higher body mass index, and cancer stage I were independent parameters associated with better survival, however, emphysema was not. This study suggests that unfavorable outcomes after surgical resection of lung cancer should not be attributed to emphysema itself.
ISSN
1011-8934
Language
English
URI
https://hdl.handle.net/10371/76473
DOI
https://doi.org/10.3346/jkms.2010.25.8.1146
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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