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Subclinical Hypothyroidism has Little Influences on Muscle Mass or Strength in Elderly People

Cited 20 time in Web of Science Cited 21 time in Scopus
Authors
Moon, Min Kyong; Lee, You Jin; Choi, Sung Hee; Lim, Soo; Lim, Jae-Young; Kim, Ki Woong; Jang, Hak C.; Park, Young Joo; Cho, Bo Youn; Park, Kyong Soo; Paik, Nam-Jong; Yang, Eun Joo
Issue Date
2010-08
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 8; 1176-1181
Keywords
SarcopeniaAgedSubclinical Hypothyroidism
Abstract
Sarcopenia, the age-related decline in muscle mass, affects the muscle strength and muscle quality, and these changes decrease functional capacity. The prevalence of thyroid dysfunction increases with age, and changes in thyroid hormone level lead to neuromuscular deficits. We investigated the effects of subclinical hypothyroidism on the muscle mass, strength or quality in elderly people. One thousand one hundred eighteen subjects aged >= 65 yr were randomly selected from a local population and classified into a euthyroid (280 men and 358 women), subclinically hypothyroid (61 men and 75 women), or overtly hypothyroid (7 men and 16 women) group. Although women with subclinical hypothyroidism had a higher prevalence of sarcopenia, defined according to the ratio of appendicular skeletal muscle mass to the square of height, muscle mass, strength or quality did not differ in relation to thyroid status in men or in women. Multivariate analysis including age, diabetes, hypertension, acute coronary event, alcohol, smoking, presence of pain, physical activity score, and lipid profile, showed that thyroid-stimulating hormone level was not associated with muscle mass, strength or quality. In conclusion, subclinical hypothyroidism has little influences on muscle mass, strength or quality, and may not be associated with sarcopenia.
ISSN
1011-8934
Language
English
URI
https://hdl.handle.net/10371/76474
DOI
https://doi.org/10.3346/jkms.2010.25.8.1176
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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