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Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress
DC Field | Value | Language |
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dc.contributor.author | Lee, Yeon Yi | - |
dc.contributor.author | Hong, Shin Hee | - |
dc.contributor.author | Lee, Ye Jin | - |
dc.contributor.author | Chung, Sung Soo | - |
dc.contributor.author | Park, Sang Gyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Jung, Hye Seung | - |
dc.date.accessioned | 2012-05-25T06:51:24Z | - |
dc.date.available | 2012-05-25T06:51:24Z | - |
dc.date.issued | 2010-07-09 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Vol.397 4; 735-739 | ko_KR |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/76480 | - |
dc.description.abstract | The exposure to acute or chronic endoplasmic reticulum (ER) stress has been known to induce dysfunction of islets, leading to apoptosis. The reduction of ER stress in islet isolation for transplantation is critical for islet protection. In this study, we investigated whether tauroursodeoxycholate (TUDCA) could inhibit ER stress induced by thapsigargin, and restore the decreased glucose stimulation index of islets. In pig islets, thapsigargin decreased the insulin secretion by high glucose stimulation in a time-dependent manner (1 h, 1.35 +/- 0.16: 2 h, 1.21 +/- 0.13; 4 h, 1.17 +/- 0.16 vs. 0 h, 1.81 +/- 0.15, n = 4, p < 0.05. respectively). However, the treatment of TUDCA restored the decreased insulin secretion index induced by thapsigargin (thapsigargin, 1.25 +/- 0.12 vs. thapsigargin + TUDCA, 2.13 +/- 0.19, n = 5, p < 0.05). Furthermore, the culture of isolated islets for 24 h with TUDCA significantly reduced the rate of islet regression (37.4 +/- 5.8% vs. 14.5 +/- 6.4%, n = 12, p < 0.05). The treatment of TUDCA enhanced ATP contents in islets (27.2 +/- 3.2 pmol/20IEQs vs. 21.7 +/- 2.8 pmol/20IEQs, n = 9, p < 0.05). The insulin secretion index by high glucose stimulation is also increased by treatment of TUDCA (2.42 +/- 0.15 vs. 1.92 +/- 0.12, n = 12, p < 0.05). Taken together, we suggest that TUDCA could be a useful agent for islet protection in islet isolation for transplantation. (C) 2010 Elsevier Inc. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | ko_KR |
dc.subject | Diabetes mellitus | ko_KR |
dc.subject | Insulin | ko_KR |
dc.subject | Islets | ko_KR |
dc.subject | ER stress | ko_KR |
dc.subject | Apoptosis | ko_KR |
dc.title | Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이연이 | - |
dc.contributor.AlternativeAuthor | 홍신희 | - |
dc.contributor.AlternativeAuthor | 이예진 | - |
dc.contributor.AlternativeAuthor | 정성수 | - |
dc.contributor.AlternativeAuthor | 정혜승 | - |
dc.contributor.AlternativeAuthor | 박상규 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.06.022 | - |
dc.citation.journaltitle | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.description.citedreference | Okamoto A, 2010, BIOCHEM BIOPH RES CO, V394, P42, DOI 10.1016/j.bbrc.2010.02.065 | - |
dc.description.citedreference | Park SG, 2010, TRANSPL INT, V23, P325, DOI 10.1111/j.1432-2277.2009.00987.x | - |
dc.description.citedreference | Hua YA, 2010, J CARDIOVASC PHARM, V55, P49 | - |
dc.description.citedreference | Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008 | - |
dc.description.citedreference | Gurzov EN, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003030 | - |
dc.description.citedreference | Noguchi H, 2008, TRANSPL P, V40, P379, DOI 10.1016/j.transproceed.2008.01.055 | - |
dc.description.citedreference | Kim JH, 2007, XENOTRANSPLANTATION, V14, P60, DOI 10.1111/j.1399-3089.2006.00364.x | - |
dc.description.citedreference | Maeda K, 2006, MOL PHARMACEUT, V3, P70, DOI 10.1021/mp050063u | - |
dc.description.citedreference | OSCAN U, 2006, SCIENCE, V313, P1137 | - |
dc.description.citedreference | Ishii S, 2005, TRANSPLANT P, V37, P3499, DOI 10.1016/j.transproceed.2005.09.134 | - |
dc.description.citedreference | Noguchi H, 2005, AM J TRANSPLANT, V5, P1848, DOI 10.1111/j.1600-6143.2005.00985.x | - |
dc.description.citedreference | Matsumoto S, 2005, LANCET, V365, P1642, DOI 10.1016/S0140-6736(05)66383-0 | - |
dc.description.citedreference | Contreras JL, 2003, TRANSPLANT INT, V16, P537, DOI 10.1007/s00147-003-0619-x | - |
dc.description.citedreference | Makishima M, 2002, SCIENCE, V296, P1313 | - |
dc.description.citedreference | XIE Q, 2002, HEPATOLOGY, V36, P592 | - |
dc.description.citedreference | Alpini GP, 2001, HEPATOLOGY, V34, P868 | - |
dc.description.citedreference | Ejiri S, 2001, TRANSPLANTATION, V71, P721 | - |
dc.description.citedreference | Xie W, 2001, P NATL ACAD SCI USA, V98, P3375 | - |
dc.description.citedreference | Shapiro AMJ, 2000, NEW ENGL J MED, V343, P230 | - |
dc.description.citedreference | Benz C, 2000, EUR J CLIN INVEST, V30, P203 | - |
dc.description.citedreference | Rosenberg L, 1999, SURGERY, V126, P393 | - |
dc.description.citedreference | Caraher EM, 1999, J ENDOCRINOL, V162, P143 | - |
dc.description.citedreference | Makishima M, 1999, SCIENCE, V284, P1362 | - |
dc.description.citedreference | Parks DJ, 1999, SCIENCE, V284, P1365 | - |
dc.description.citedreference | Wang HB, 1999, MOL CELL, V3, P543 | - |
dc.description.citedreference | Invernizzi P, 1999, HEPATOLOGY, V29, P320 | - |
dc.description.citedreference | Marchesa P, 1997, AM J GASTROENTEROL, V92, P1285 | - |
dc.description.citedreference | Baumgartner U, 1996, DIGEST DIS SCI, V41, P250 | - |
dc.description.citedreference | Shekels LL, 1996, J LAB CLIN MED, V127, P57 | - |
dc.description.citedreference | PONGRACZ J, 1995, INT J CANCER, V61, P35 | - |
dc.description.citedreference | BEUERS U, 1993, J CLIN INVEST, V92, P2984 | - |
dc.description.citedreference | CRAVEN PA, 1986, CANCER RES, V46, P5754 | - |
dc.description.citedreference | DERUBERTIS FR, 1984, J CLIN INVEST, V74, P1614 | - |
dc.description.tc | 7 | - |
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