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Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis

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dc.contributor.authorKim, Jung Mogg-
dc.contributor.authorKang, Hyoun Woo-
dc.contributor.authorCha, Mi Yeon-
dc.contributor.authorYoo, Doyoung-
dc.contributor.authorKim, In-Kyoung-
dc.contributor.authorKim, Sunil-
dc.contributor.authorJung, Hyun Chae-
dc.contributor.authorKim, Joo Sung-
dc.contributor.authorSong, In Sung-
dc.contributor.authorMa, Sang-Ho-
dc.contributor.authorKu, Jeounghun-
dc.contributor.authorKim, Nayoung-
dc.date.accessioned2012-05-25T07:05:10Z-
dc.date.available2012-05-25T07:05:10Z-
dc.date.issued2010-07-
dc.identifier.citationLABORATORY INVESTIGATION; Vol.90 7; 1004-1015ko_KR
dc.identifier.issn0023-6837-
dc.identifier.urihttps://hdl.handle.net/10371/76482-
dc.description.abstractWe already showed that the plant sterol guggulsterone has been reported to inhibit nuclear factor-κB (NF-κB) signaling in intestinal epithelial cells (IECs) and to attenuate dextran sulfate sodium (DSS)-induced colitis. This study investigates the anti-inflammatory effects of novel guggulsterone derivatives on IEC and preventive and therapeutic murine models of DSS-induced colitis. Novel guggulsterone derivates with high lipophilicity were designed and four derivates, including GG-46, GG-50B, GG-52, and GG-53, were synthesized. Two guggulsterone derivatives, GG-50B and GG-52, significantly inhibited the activated NF-κB signals and the upregulated expression of interleukin-8 (IL-8) in COLO 205 cells stimulated with tumor necrosis factor-α (TNF-α). Pretreatment with GG-50B and GG-52 attenuated the increased I κB kinase (IKK) and I κBα phsophorylation induced by TNF-α. In preventive and therapeutic models of murine colitis, administration of GG-52 significantly reduced the severity of DSS-induced colitis, as assessed by disease activity index, colon length, and histology. In contrast, GG-50B did not show a significant reduction in the colitis severity. Moreover, the efficacy on attenuating colitis by GG-52 was comparable to that by sulfasalazine or prednisolone. These results indicate that the novel guggulsterone derivative GG-52 blocks NF-κB activation in IEC and ameliorates DSS-induced acute murine colitis, which suggests that GG-52 is a potential therapeutic agent for the treatment of inflammatory bowel diseases. Laboratory Investigation (2010) 90, 1004-1015; doi: 10.1038/labinvest.2010.54; published online 1 March 2010ko_KR
dc.language.isoenko_KR
dc.publisherNATURE PUBLISHING GROUPko_KR
dc.subjectguggulsterone derivativesko_KR
dc.subjectmurine colitisko_KR
dc.subjectinflammatory bowel diseaseko_KR
dc.subjectNF-κBko_KR
dc.titleNovel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김정목-
dc.contributor.AlternativeAuthor강현우-
dc.contributor.AlternativeAuthor차미연-
dc.contributor.AlternativeAuthor유도영-
dc.contributor.AlternativeAuthor김나영-
dc.contributor.AlternativeAuthor김인경-
dc.contributor.AlternativeAuthor구정훈-
dc.contributor.AlternativeAuthor김선일-
dc.contributor.AlternativeAuthor마상호-
dc.contributor.AlternativeAuthor정현채-
dc.contributor.AlternativeAuthor송인성-
dc.contributor.AlternativeAuthor김주성-
dc.identifier.doi10.1038/labinvest.2010.54-
dc.citation.journaltitleLABORATORY INVESTIGATION-
dc.description.citedreferenceBraus NA, 2009, CLIN IMMUNOL, V132, P1, DOI 10.1016/j.clim.2009.02.006-
dc.description.citedreferenceLee JY, 2009, J MOL MED-JMM, V87, P169, DOI 10.1007/s00109-008-0415-2-
dc.description.citedreferenceMcGuckin MA, 2009, INFLAMM BOWEL DIS, V15, P100, DOI 10.1002/ibd.20539-
dc.description.citedreferenceChichlowski M, 2008, AM J PHYSIOL-GASTR L, V295, pG1139, DOI 10.1152/ajpgi.90516.2008-
dc.description.citedreferenceAtreya I, 2008, J INTERN MED, V263, P591, DOI 10.1111/j.1365-2796.2008.01953.x-
dc.description.citedreferenceNam SY, 2008, EXP BIOL MED, V233, P180-
dc.description.citedreferenceMCGUCKIN MA, 2008, INFLAMM BOWEL DIS, V15, P100-
dc.description.citedreferenceKim JM, 2007, INFECT IMMUN, V75, P3373, DOI 10.1128/IAI.01940-06-
dc.description.citedreferenceLee JY, 2007, INT IMMUNOPHARMACOL, V7, P241, DOI 10.1016/j.intimp.2006.10.013-
dc.description.citedreferenceCheon JH, 2006, INFLAMM BOWEL DIS, V12, P1152-
dc.description.citedreferenceKim JM, 2006, EUR J IMMUNOL, V36, P2446, DOI 10.1002/eji.200535808-
dc.description.citedreferenceTerracciano S, 2006, CURR MED CHEM, V13, P1947-
dc.description.citedreferenceMA TY, 2006, PHYSL GASTROINTESTIN, P1559-
dc.description.citedreferencevan Staa TP, 2005, GUT, V54, P1573, DOI 10.1136/gut.2005.070896-
dc.description.citedreferenceIsaacs KL, 2005, INFLAMM BOWEL DIS, V11, pS3-
dc.description.citedreferenceKim JM, 2005, EUR J IMMUNOL, V35, P2648, DOI 10.1002/eji.200526321-
dc.description.citedreferenceGreten FR, 2004, CELL, V118, P285-
dc.description.citedreferenceMa TY, 2004, AM J PHYSIOL-GASTR L, V286, pG367, DOI 10.1152/ajpgi.00173.2003-
dc.description.citedreferenceNeish AS, 2004, INFLAMM BOWEL DIS, V10, P159-
dc.description.citedreferenceUrizar NL, 2003, ANNU REV NUTR, V23, P303, DOI 10.1146/annurev.nutr.23.011702.073102-
dc.description.citedreferenceCho NH, 2002, INFECT IMMUN, V70, P4841, DOI 10.1128/IAI.70.9.4841-4850.2002-
dc.description.citedreferenceSCHEIFFELE F, 2002, CURR PROTOC IMMUNOL, pCH15-
dc.description.citedreferenceKim JM, 2001, CLIN EXP IMMUNOL, V123, P421-
dc.description.citedreferenceBantel H, 2000, AM J GASTROENTEROL, V95, P3452-
dc.description.citedreferenceWeber CK, 2000, GASTROENTEROLOGY, V119, P1209, DOI 10.1053/gast.2000.19458-
dc.description.citedreferenceJobin C, 2000, INFLAMM BOWEL DIS, V6, P206-
dc.description.citedreferenceCaradonna L, 2000, J ENDOTOXIN RES, V6, P205-
dc.description.citedreferenceElewaut D, 1999, J IMMUNOL, V163, P1457-
dc.description.citedreferenceDieleman LA, 1998, CLIN EXP IMMUNOL, V114, P385-
dc.description.citedreferenceNeurath MF, 1998, GUT, V43, P856-
dc.description.citedreferenceMay MJ, 1998, IMMUNOL TODAY, V19, P80-
dc.description.citedreferenceNEURATH MF, 1995, J EXP MED, V182, P1281-
dc.description.citedreferenceAUPHAN N, 1995, SCIENCE, V270, P286-
dc.description.citedreferenceCOOPER HS, 1993, LAB INVEST, V69, P238-
dc.description.citedreferenceZHOU W, GASTROENTEROLOGY, V137, P1403-
dc.description.tc1-
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