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Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Kang, Hyoun Woo | - |
dc.contributor.author | Cha, Mi Yeon | - |
dc.contributor.author | Yoo, Doyoung | - |
dc.contributor.author | Kim, In-Kyoung | - |
dc.contributor.author | Kim, Sunil | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Ma, Sang-Ho | - |
dc.contributor.author | Ku, Jeounghun | - |
dc.contributor.author | Kim, Nayoung | - |
dc.date.accessioned | 2012-05-25T07:05:10Z | - |
dc.date.available | 2012-05-25T07:05:10Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | LABORATORY INVESTIGATION; Vol.90 7; 1004-1015 | ko_KR |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76482 | - |
dc.description.abstract | We already showed that the plant sterol guggulsterone has been reported to inhibit nuclear factor-κB (NF-κB) signaling in intestinal epithelial cells (IECs) and to attenuate dextran sulfate sodium (DSS)-induced colitis. This study investigates the anti-inflammatory effects of novel guggulsterone derivatives on IEC and preventive and therapeutic murine models of DSS-induced colitis. Novel guggulsterone derivates with high lipophilicity were designed and four derivates, including GG-46, GG-50B, GG-52, and GG-53, were synthesized. Two guggulsterone derivatives, GG-50B and GG-52, significantly inhibited the activated NF-κB signals and the upregulated expression of interleukin-8 (IL-8) in COLO 205 cells stimulated with tumor necrosis factor-α (TNF-α). Pretreatment with GG-50B and GG-52 attenuated the increased I κB kinase (IKK) and I κBα phsophorylation induced by TNF-α. In preventive and therapeutic models of murine colitis, administration of GG-52 significantly reduced the severity of DSS-induced colitis, as assessed by disease activity index, colon length, and histology. In contrast, GG-50B did not show a significant reduction in the colitis severity. Moreover, the efficacy on attenuating colitis by GG-52 was comparable to that by sulfasalazine or prednisolone. These results indicate that the novel guggulsterone derivative GG-52 blocks NF-κB activation in IEC and ameliorates DSS-induced acute murine colitis, which suggests that GG-52 is a potential therapeutic agent for the treatment of inflammatory bowel diseases. Laboratory Investigation (2010) 90, 1004-1015; doi: 10.1038/labinvest.2010.54; published online 1 March 2010 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | NATURE PUBLISHING GROUP | ko_KR |
dc.subject | guggulsterone derivatives | ko_KR |
dc.subject | murine colitis | ko_KR |
dc.subject | inflammatory bowel disease | ko_KR |
dc.subject | NF-κB | ko_KR |
dc.title | Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정목 | - |
dc.contributor.AlternativeAuthor | 강현우 | - |
dc.contributor.AlternativeAuthor | 차미연 | - |
dc.contributor.AlternativeAuthor | 유도영 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 김인경 | - |
dc.contributor.AlternativeAuthor | 구정훈 | - |
dc.contributor.AlternativeAuthor | 김선일 | - |
dc.contributor.AlternativeAuthor | 마상호 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.identifier.doi | 10.1038/labinvest.2010.54 | - |
dc.citation.journaltitle | LABORATORY INVESTIGATION | - |
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dc.description.tc | 1 | - |
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