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Efficacy of computed virtual chromoendoscopy on colorectal cancer screening: a prospective, randomized, back-to-back trial of Fuji Intelligent Color Enhancement versus conventional colonoscopy to compare adenoma miss rates

Cited 64 time in Web of Science Cited 70 time in Scopus
Authors
Chung, Su Jin; Kim, Donghee; Song, Ji Hyun; Park, Min Jung; Kim, Joo Sung; Song, In Sung; Jung, Hyun Chae; Kim, Young Sun
Issue Date
2010-07
Publisher
MOSBY-ELSEVIER
Citation
GASTROINTESTINAL ENDOSCOPY; Vol.72 1; 136-142
Abstract
Background: Colonoscopy is the criterion standard for screening of colorectal neoplasms. Nonetheless, a substantial miss rate with conventional, white-light colonoscopy (XL) remains a challenge. Objective: To assess whether Fuji Intelligent Color Enhancement (FICE) can detect more adenomas than WL in screening colonoscopy. Design: Prospective, randomized trial of tandem colonoscopy adjusted for withdrawal time and lavage effect. Setting: Seoul National University Hospital Healthcare System Gangnam Center, Korea. Patients: This study involved 359 average-risk adults undergoing screening colonoscopy. Intervention: Patients were randomized to the first withdrawal with either FICE (FICE-WL group) or WL (WL-FICE group). Main Outcome Measurements: The primary end point measure was the difference in adenoma miss rates, and the secondary outcome measure was the adenoma detection rate. Results: We enrolled 359 patients (mean age 50.6 years, male 66.9%) and randomly assigned 181 to the WL-FICE group and 178 to the FICE-WL group. The number of adenomas detected by FICE and WL was 123 and 107, respectively. The adenoma miss rate with FICE showed no significant difference compared with that of WL (6.6% vs 8.3%, P = .59). Characteristics of lesions missed by use of FICE were similar to those missed by use of WL; 93% of overall missed polyps were mm, and none were cm. All missed adenomas were low grade and nonpedunculated. There was no significant difference between FICE and WL in adenoma detection rate (mean 0.64 vs 0.55 per patient, P = .65) nor percentage of patients with >= 1 adenoma (33.7% vs 30.4%, P = .74). Limitations: Single-center study. Conclusion: FICE at screening colonoscopy did not improve the adenoma miss rate or detection rate compared with WL. (Gastrointest Endosc 2010;72:136-42.)
ISSN
0016-5107
Language
English
URI
http://hdl.handle.net/10371/76484
DOI
https://doi.org/10.1016/j.gie.2010.01.055
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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