Publications
Detailed Information
Association between matrix metalloproteinase 9 promoter polymorphisms and Behcets disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Kang, Seong Wook | - |
dc.contributor.author | Baek, Han Joo | - |
dc.contributor.author | Choi, Hyo Jin | - |
dc.contributor.author | Kang, Eun Ha | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Bae, Young Deok | - |
dc.date.accessioned | 2012-05-25T07:28:07Z | - |
dc.date.available | 2012-05-25T07:28:07Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | HUMAN IMMUNOLOGY; Vol.71 7; 717-722 | ko_KR |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76485 | - |
dc.description.abstract | Matrix metalloproteinase (MMP)-9 expression is reported to be upregulated in several primary vasculitides. The -1562C>T and 91 [CA](n) repeat polymorphisms can affect MMP-9 promoter activity. We investigated the distributions of these functional polymorphisms in 122 patients with Behcet`s disease (BD) and in 122 gender- and age-matched healthy controls. Plasma levels of MMP-9 were analyzed. The frequency of "L" alleles with [CA](n) <21 was significantly lower in all BD patients (vs controls, odds ratio (OR) = 0.371 [95% confidence interval 0.152-0.905]) and male patients (vs male controls, OR = 0.117 [0.019-0.737]). Furthermore, the frequency of "H/H" homozygote with [CA](n) >= 21 was significantly higher in BD patients than controls (OR = 2.677 [1.065-6.7291). Moreover, the frequency of CL haplotype with lower promoter activity was significantly lower in BD patients (vs controls, OR = 0.374 [0.149-0.939]) and in BD patients with visceral involvement (OR = 0.202 10.044-0.916]). Although plasma MMP-9 levels were not different between controls and BD patients, concentrations of this substance were significantly higher in male patients (vs male controls, p = 0.044) or patients with visceral involvements (vs patients without visceral involvement, p = 0.027). These results suggest that MMP-9 is a novel susceptibility gene and its promoter polymorphisms can affect the development of visceral involvement in BD. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Behcet`s disease | ko_KR |
dc.subject | Matrix metalloproteinase-9 | ko_KR |
dc.subject | Polymorphism | ko_KR |
dc.subject | Promoter | ko_KR |
dc.title | Association between matrix metalloproteinase 9 promoter polymorphisms and Behcets disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이윤종 | - |
dc.contributor.AlternativeAuthor | 강성욱 | - |
dc.contributor.AlternativeAuthor | 백한주 | - |
dc.contributor.AlternativeAuthor | 최효진 | - |
dc.contributor.AlternativeAuthor | 배영덕 | - |
dc.contributor.AlternativeAuthor | 강은하 | - |
dc.contributor.AlternativeAuthor | 이은영 | - |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.identifier.doi | 10.1016/j.humimm.2010.03.009 | - |
dc.citation.journaltitle | HUMAN IMMUNOLOGY | - |
dc.description.citedreference | Cauwe B, 2009, INTEGR BIOL, V1, P404, DOI 10.1039/b904701h | - |
dc.description.citedreference | Vokurka J, 2009, ARCH ORAL BIOL, V54, P172, DOI 10.1016/j.archoralbio.2008.09.002 | - |
dc.description.citedreference | Rodriguez-Pla A, 2008, ARTHRITIS RHEUM-US, V58, P1849, DOI 10.1002/art.23457 | - |
dc.description.citedreference | Rayment EA, 2008, BRIT J DERMATOL, V158, P951, DOI 10.1111/j.1365-2133.2008.08462.x | - |
dc.description.citedreference | Oviedo-Orta E, 2008, IMMUNOLOGY, V124, P42, DOI 10.1111/j.1365-2567.2007.02728.x | - |
dc.description.citedreference | Mannello F, 2008, ANAL BIOCHEM, V374, P56, DOI 10.1016/j.ab.2007.11.020 | - |
dc.description.citedreference | Demacq C, 2008, CLIN CHEM LAB MED, V46, P57, DOI 10.1515/CCLM.2008.014 | - |
dc.description.citedreference | Sanders JSF, 2007, AM J PHYSIOL-RENAL, V293, pF1927, DOI 10.1152/ajprenal.00310.2007 | - |
dc.description.citedreference | Pay S, 2007, CLIN EXP RHEUMATOL, V25, pS70 | - |
dc.description.citedreference | Saadoun D, 2007, ARTHRITIS RHEUM, V56, P1315, DOI 10.1002/art.22456 | - |
dc.description.citedreference | Flex A, 2006, J GERONTOL A-BIOL, V61, P1065 | - |
dc.description.citedreference | Khandoga A, 2006, J LEUKOCYTE BIOL, V79, P1295, DOI 10.1189/jlb.0805468 | - |
dc.description.citedreference | Fiotti N, 2006, ARTERIOSCL THROM VAS, V26, P1330, DOI 10.1161/01.ATV.0000219233.31702.c9 | - |
dc.description.citedreference | Chen P, 2006, TOHOKU J EXP MED, V208, P261 | - |
dc.description.citedreference | Zou CC, 2006, SCAND J RHEUMATOL, V35, P52, DOI 10.1080/03009740510026940 | - |
dc.description.citedreference | Castaneda FE, 2005, GASTROENTEROLOGY, V129, P1991, DOI 10.1053/j.gastro.2005.09.017 | - |
dc.description.citedreference | Ito I, 2005, AM J RESP CRIT CARE, V172, P1378, DOI 10.1164/rccm.200506-953OC | - |
dc.description.citedreference | Xue ML, 2005, INT J BIOCHEM CELL B, V37, P2406, DOI 10.1016/j.biocel.2005.06.003 | - |
dc.description.citedreference | Fahling M, 2005, BBA-GENE STRUCT EXPR, V1731, P32, DOI 10.1016/j.bbaexp.2005.08.005 | - |
dc.description.citedreference | Karasneh J, 2005, ARTHRITIS RHEUM, V52, P1836, DOI 10.1002/art.21060 | - |
dc.description.citedreference | Pozo P, 2005, J PERIODONTAL RES, V40, P199, DOI 10.1111/j.1600-0765.2005.00786.x | - |
dc.description.citedreference | Fiotti N, 2005, GENET MED, V7, P272, DOI 10.1097/01.GIM.0000159903.69597.73 | - |
dc.description.citedreference | Matsumura S, 2005, J CANCER RES CLIN, V131, P19, DOI 10.1007/s00432-004-0621-4 | - |
dc.description.citedreference | Tayebjee MH, 2005, J INTERN MED, V257, P110 | - |
dc.description.citedreference | Kodama D, 2004, J NEUROIMMUNOL, V156, P188, DOI 10.1016/j.jneuroim.2004.07.007 | - |
dc.description.citedreference | Abu El-Asrar AM, 2004, AM J OPHTHALMOL, V138, P401, DOI 10.1016/j.ajo.2004.04.046 | - |
dc.description.citedreference | Parks WC, 2004, NAT REV IMMUNOL, V4, P617, DOI 10.1038/nri1418 | - |
dc.description.citedreference | Jones GT, 2003, J VASC SURG, V38, P1363, DOI 10.1016/S0741-5214(03)01027-9 | - |
dc.description.citedreference | Stephens M, 2003, AM J HUM GENET, V73, P1162 | - |
dc.description.citedreference | Matsuyama A, 2003, CIRCULATION, V108, P1469, DOI 10.1161/01.CIR.0000090689.69973.B1 | - |
dc.description.citedreference | Lee KH, 2003, ARTHRITIS RHEUM, V48, P2025, DOI 10.1002/art.11074 | - |
dc.description.citedreference | Hirakawa S, 2003, AM J KIDNEY DIS, V42, P133, DOI 10.1016/S0272-6386(03)00416-5 | - |
dc.description.citedreference | Mattos W, 2002, CHEST, V122, P1543 | - |
dc.description.citedreference | Van Den Steen PE, 2002, FASEB J, V16 | - |
dc.description.citedreference | Evereklioglu C, 2002, J AM ACAD DERMATOL, V46, P50, DOI 10.1067/mjd.2002.118338 | - |
dc.description.citedreference | Zhang BP, 2001, STROKE, V32, P2198 | - |
dc.description.citedreference | Takeshita S, 2001, CLIN EXP IMMUNOL, V125, P340 | - |
dc.description.citedreference | Krause I, 2001, J RHEUMATOL, V28, P1033 | - |
dc.description.citedreference | Perez P, 2000, ARTHRITIS RHEUM, V43, P2807 | - |
dc.description.citedreference | Creange A, 1999, NEUROLOGY, V53, P1683 | - |
dc.description.citedreference | Lichtinghagen R, 1999, J NEUROIMMUNOL, V99, P19 | - |
dc.description.citedreference | Shimajiri S, 1999, FEBS LETT, V455, P70 | - |
dc.description.citedreference | Zhang BP, 1999, CIRCULATION, V99, P1788 | - |
dc.description.citedreference | Kumagai K, 1999, J IMMUNOL, V162, P4212 | - |
dc.description.citedreference | Sehgal I, 1999, MOL BIOL CELL, V10, P407 | - |
dc.description.citedreference | Sorbi D, 1996, ARTHRITIS RHEUM, V39, P1747 | - |
dc.description.citedreference | Delclaux C, 1996, AM J RESP CELL MOL, V14, P288 | - |
dc.description.citedreference | LEPPERT D, 1995, J IMMUNOL, V154, P4379 | - |
dc.description.citedreference | SILMAN AJ, 1990, LANCET, V335, P1078 | - |
dc.description.tc | 2 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.