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Pediatric Moyamoya Disease: An Analysis of 410 Consecutive Cases
DC Field | Value | Language |
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dc.contributor.author | Kim, Seung-Ki | - |
dc.contributor.author | Cho, Byung-Kyu | - |
dc.contributor.author | Phi, Ji Hoon | - |
dc.contributor.author | Lee, Ji Yeoun | - |
dc.contributor.author | Kim, Ki Joong | - |
dc.contributor.author | Kim, In-One | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Wang, Kyu-Chang | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Hwang, Yong-Seung | - |
dc.contributor.author | Chae, Jong Hee | - |
dc.date.accessioned | 2012-05-25T07:30:57Z | - |
dc.date.available | 2012-05-25T07:30:57Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | ANNALS OF NEUROLOGY; Vol.68 1; 92-101 | ko_KR |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76486 | - |
dc.description.abstract | Objective: Moyamoya disease (MMD) is a cerebrovascular occlusive disease of the bilateral internal carotid arteries that causes a compensatory abnormal vascular network at the base of brain. The rare incidence and various surgical techniques applied have limited the clinical research on MMD. Methods: We conducted a retrospective analysis of the surgical outcome of 410 pediatric MMD patients. All patients were treated in a relatively uniform scheme at a single institution. The surgical procedures consisted of bilateral encephaloduroarteriosynangiosis augmented by bifrontal encephalogaleo-/periosteal synangiosis. Logistic regression analyses were applied to reveal the prognostic factors for surgical outcome. Results: The overall clinical outcome was excellent in 66%, good in 15%, fair in 15%, and poor in 4% of the patients. Therefore, 81% of the patients had a favorable clinical outcome (excellent and good). Multivariate analyses revealed that infarction on presentation was associated with unfavorable clinical outcome (odds ratio [OR], 2.85; 95% confidence interval [CI], 1.49-5.46; p < 0.01) and decreased vascular reserve only on single-photon emission computerized tomography (OR, 0.07; 95% CI, 0.01-0.52; p < 0.01), with favorable clinical outcome. Interpretation: Our results indicate that an early diagnosis and active intervention before establishment of irreversible hemodynamic change are essential to achieve a favorable clinical outcome in children with MMD. ANN NEUROL 2010;68:92-101 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL | ko_KR |
dc.title | Pediatric Moyamoya Disease: An Analysis of 410 Consecutive Cases | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김승기 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
dc.contributor.AlternativeAuthor | 피지훈 | - |
dc.contributor.AlternativeAuthor | 이지연 | - |
dc.contributor.AlternativeAuthor | 채종희 | - |
dc.contributor.AlternativeAuthor | 김기중 | - |
dc.contributor.AlternativeAuthor | 황용승 | - |
dc.contributor.AlternativeAuthor | 김인원 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 이중엽 | - |
dc.contributor.AlternativeAuthor | 왕규창 | - |
dc.identifier.doi | 10.1002/ana.21981 | - |
dc.citation.journaltitle | ANNALS OF NEUROLOGY | - |
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dc.description.tc | 10 | - |
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