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Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Kim, Donghee | - |
dc.contributor.author | Kim, Hwa Jung | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yang, Jong In | - |
dc.date.accessioned | 2012-05-25T07:40:47Z | - |
dc.date.available | 2012-05-25T07:40:47Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | DIGESTIVE AND LIVER DISEASE; Vol.42 7; 503-508 | ko_KR |
dc.identifier.issn | 1590-8658 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76487 | - |
dc.description.abstract | Background/Aims: To optimize management of nonalcoholic fatty liver disease (NAFLD), a simple screening tool is necessary. In this study, we aimed to devise a simple index of NAFLD. Study: A cross-sectional study with 10,724 health check-up subjects (5362 cases with NAFLD versus age- and sex-matched controls) was conducted. Study subjects were randomly assigned to a derivation cohort or a validation cohort. Results: Multivariate analysis indicated that high serum alanine aminotransferase (ALT) to serum aspartate aminotransferase (AST) ratio, high body mass index (BMI), and diabetes mellitus were independent risk factors of NAFLD (all P<0.001). Using these variables, a formula was derived by a logistic regression model: hepatic steatosis index (HSI) = 8 x (ALT/AST ratio) + BMI (+2, if female; +2, if diabetes mellitus). HSI had an area under receiver-operating curve of 0.812 (95% confidence interval, 0.801-0.824). At values of <30.0 or >36.0, HSI ruled out NAFLD with a sensitivity of 93.1%, or detected NAFLD with a specificity of 92.4%, respectively. Of 2692 subjects with HSI <30.0 or >36.0 in the derivation cohort, 2305 (85.6%) were correctly classified. HSI was validated in the subsequent validation cohort. Conclusion: HSI is a simple, efficient screening tool for NAFLD that may be utilized for selecting individuals for liver ultrasonography and for determining the need for lifestyle modifications. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Body mass index | ko_KR |
dc.subject | Fatty liver | ko_KR |
dc.subject | Screening | ko_KR |
dc.subject | Hepatic steatosis index | ko_KR |
dc.title | Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이정훈 | - |
dc.contributor.AlternativeAuthor | 김동희 | - |
dc.contributor.AlternativeAuthor | 김화정 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.contributor.AlternativeAuthor | 양종인 | - |
dc.contributor.AlternativeAuthor | 김원 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.1016/j.dld.2009.08.002 | - |
dc.citation.journaltitle | DIGESTIVE AND LIVER DISEASE | - |
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dc.description.tc | 5 | - |
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