S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
The immunosuppressive effect of embryonic stem cells and mesenchymal stem cells on both primary and secondary alloimmune responses
- Han, Kyu Hyun; Kang, Hee Gyung; Gil, Hae Jin; Lee, Eun Mi; Yang, Jaeseok; Ahn, Curie
- Issue Date
- ELSEVIER SCIENCE BV
- TRANSPLANT IMMUNOLOGY; Vol.23 3; 141-146
- Embryonic stem cells; Transplantation; Sensitization; Immunosuppression; Mesenchymal stem cells
- Recently, both embryonic stem cells and mesenchymal stem cells have been demonstrated to have immunosuppressive effects. The purpose of this study was to elucidate whether the embryonic stem cells and/or mesenchymal stem cells modulate both primary and secondary alloimmune responses. Both stem cells suppressed in vitro proliferation and cytokine production in primary alloimmune responses. They also suppressed in vitro proliferation and cytokine production of the allosensitized CD44(+) memory T cells. However, they failed to prolong skin graft survival across both a major mismatch barrier (BALB/C, C57BL6/J) and a minor mismatch barrier (male to female). In conclusion, both embryonic stem cells and mesenchymal stem cells can suppress secondary alloimmune response in vitro as well as primary alloimmune responses; however, neither embryonic stem cells nor mesenchymal stem cells suppressed allograft rejection in stringent murine skin transplantation models. (C) 2010 Elsevier B.V. All rights reserved.
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