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Tacrolimus is an alternative therapeutic option for the treatment of refractory lupus nephritis

Cited 27 time in Web of Science Cited 31 time in Scopus
Issue Date
2010-07
Publisher
SAGE PUBLICATIONS LTD
Citation
LUPUS; Vol.19 8; 974-980
Keywords
lupus nephritistacrolimusproteinuriasystemic lupus erythematosus
Abstract
We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had failed to respond to sufficient intravenous cyclophosphamide therapy with proteinuria of >= 1 g/day and active urinary sediments. Tacrolimus (0.1 mg/kg/day) was administered for 1 year with adjusting drug level (4-10 mg/l). The mean serum creatinine level and spot urine protein creatinine ratio (UPCR) at baseline were 1.39 mg/dl and 2.27, respectively. After the treatment, proteinuria reduced significantly from median UPCR value of 2.19 (range, 1.19-3.34) to 0.44 (range, 0.12-2.13) (p < 0.05). Seven (78%) of the nine patients showed a complete clinical response, which was defined as stabilization in the disease-activity markers and serum creatinine level with reduction of >= 50% in UPCR; two patients showed complete remission with UPCR <0.2. One patient showed treatment failure because of the disease progression. No serious adverse effects were observed during the study. This study demonstrates that tacrolimus can show a significant therapeutic response in cases that are refractory to the standard regimen for diffuse proliferative lupus nephritis. Lupus (2010) 19, 974-980.
ISSN
0961-2033
Language
English
URI
https://hdl.handle.net/10371/76492
DOI
https://doi.org/10.1177/0961203310366573
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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