Browse

Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer

DC Field Value Language
dc.contributor.authorYoo, Eun Joo-
dc.contributor.authorPark, Seog-Yun-
dc.contributor.authorCho, Nam-Yun-
dc.contributor.authorKim, Nayoung-
dc.contributor.authorKim, Donguk-
dc.contributor.authorKang, Gyeong Hoon-
dc.contributor.authorLee, Hye Seung-
dc.date.accessioned2012-05-29T01:47:03Z-
dc.date.available2012-05-29T01:47:03Z-
dc.date.issued2010-06-
dc.identifier.citationVIRCHOWS ARCHIV; Vol.456 6; 647-652ko_KR
dc.identifier.issn0945-6317-
dc.identifier.urihttps://hdl.handle.net/10371/76516-
dc.description.abstractHelicobacter pylori infection can induce aberrant CpG island hypermethylation in gastric mucosal epithelial cells. Single nucleotide polymorphisms of proinflammatory cytokine genes encoding for interleukin 1B (IL1B), IL6, and IL8 have been demonstrated to be associated with an increased risk of gastric cancer. To identify the influence of host genetic factors in CpG island hypermethylation induced by H. pylori infection, we analyzed H. pylori-infected chronic gastritis (n = 111) and gastric cancer samples (n = 78) for the methylation status of eight genes previously shown to be hypermethylated in chronic gastritis and single nucleotide polymorphisms of IL1B, IL6, and IL8. The methylation levels were then compared between different genotypes. Gastric cancers from patients with the IL1B-511T/T allele showed significantly higher methylation levels in five genes as compared with gastric cancers from IL1B-511 C carriers (P < 0.05). An increased level of hypermethylation in association with the IL1B-511T/T allele was observed in chronic gastritis samples, but the association was not statistically significant. These findings suggest that the IL1B-511T/T allele is associated with enhanced hypermethylation of multiple CpG island loci, which might contribute to an increase in the risk for gastric cancer in individuals with H. pylori infection and IL1B-511T/T allele.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectDNA methylationko_KR
dc.subjectHelicobacter pyloriko_KR
dc.subjectIL1Bko_KR
dc.subjectSingle nucleotide polymorphismko_KR
dc.titleInfluence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor유은주-
dc.contributor.AlternativeAuthor박석윤-
dc.contributor.AlternativeAuthor조남윤-
dc.contributor.AlternativeAuthor김나영-
dc.contributor.AlternativeAuthor이혜승-
dc.contributor.AlternativeAuthor김동욱-
dc.contributor.AlternativeAuthor강경훈-
dc.identifier.doi10.1007/s00428-010-0918-4-
dc.citation.journaltitleVIRCHOWS ARCHIV-
dc.description.citedreferenceYoo EJ, 2008, VIRCHOWS ARCH, V452, P515, DOI 10.1007/s00428-008-0596-7-
dc.description.citedreferenceKang GH, 2008, LAB INVEST, V88, P161, DOI 10.1038/labinvest.3700707-
dc.description.citedreferencePerri F, 2007, AM J GASTROENTEROL, V102, P1361, DOI 10.1111/j.1572-0241.2007.01284.x-
dc.description.citedreferenceChan AOO, 2007, GUT, V56, P595, DOI 10.1136/gut.2006.113258-
dc.description.citedreferenceWidschwendter M, 2007, NAT GENET, V39, P157-
dc.description.citedreferenceSchlesinger Y, 2007, NAT GENET, V39, P232, DOI 10.1038/ng1950-
dc.description.citedreferenceOhm JE, 2007, NAT GENET, V39, P237, DOI 10.1038/ng1972-
dc.description.citedreferenceLi C, 2007, J GASTROEN HEPATOL, V22, P234, DOI 10.1111/j.1440-1746.2006.04379.x-
dc.description.citedreferenceWehbe H, 2006, CANCER RES, V66, P10517, DOI 10.1158/0008-5472.CAN-06-2130-
dc.description.citedreferenceMihara M, 2006, AM J PATHOL, V169, P1643, DOI 10.2353/ajpath.2006.060552-
dc.description.citedreferenceLeung WK, 2006, CLIN CANCER RES, V12, P3216, DOI 10.1158/1078-0432.CCR-05-2442-
dc.description.citedreferenceUshijima T, 2006, J GASTROENTEROL, V41, P401, DOI 10.1007/s00535-006-1846-6-
dc.description.citedreferenceOgino S, 2006, J MOL DIAGN, V8, P209, DOI 10.2353/jmoldx.2006.050135-
dc.description.citedreferenceLee TI, 2006, CELL, V125, P301-
dc.description.citedreferenceChan AOO, 2006, GUT, V55, P463, DOI 10.1136/gut.2005.077776-
dc.description.citedreferenceMaekita T, 2006, CLIN CANCER RES, V12, P989, DOI 10.1158/1078-0432.CCR-05-2096-
dc.description.citedreferenceTaguchi A, 2005, CANCER EPIDEM BIOMAR, V14, P2487, DOI 10.1158/1055-9965.EPI-05-0326-
dc.description.citedreferenceHodge DR, 2005, CANCER RES, V65, P4673-
dc.description.citedreferenceChang YW, 2005, INT J CANCER, V114, P465, DOI 10.1002/ijc.20724-
dc.description.citedreferenceChan AOO, 2003, GUT, V52, P502-
dc.description.citedreferenceHwang IR, 2002, GASTROENTEROLOGY, V123, P1793, DOI 10.1053/gast.2002.37043-
dc.description.citedreferenceTrinh BN, 2001, METHODS, V25, P456, DOI 10.1006/meth.2001.1268-
dc.description.citedreferenceHodge DR, 2001, J BIOL CHEM, V276, P39508-
dc.description.citedreferenceTerry CF, 2000, J BIOL CHEM, V275, P18138-
dc.description.citedreferenceEl-Omar EM, 2000, NATURE, V404, P398-
dc.description.citedreferenceEADS CA, 2000, NUCLEIC ACIDS RES, V28, P32, DOI DOI 10.1093/NAR/28.8.E32-
dc.description.citedreferenceHmadcha A, 1999, J EXP MED, V190, P1595-
dc.description.citedreferenceWang MC, 1999, J GASTROENTEROL, V34, P10-
dc.description.citedreferenceJones PA, 1999, NAT GENET, V21, P163-
dc.description.citedreferenceFishman D, 1998, J CLIN INVEST, V102, P1369-
dc.description.citedreferenceOlomolaiye O, 1998, EUR J IMMUNOGENET, V25, P267-
dc.description.citedreference*IARC WORK GROUP E, 1994, IARC MON EV CARC RIS, V61, P1-
dc.description.citedreferenceWALLACE JL, 1991, AM J PHYSIOL, V261, P559-
dc.description.tc3-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse