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Genetic immunotherapy of lung cancer using conditionally replicating adenovirus and adenovirus-interferon-beta
DC Field | Value | Language |
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dc.contributor.author | Park, M-Y | - |
dc.contributor.author | Kim, D. R. | - |
dc.contributor.author | Jung, H. W. | - |
dc.contributor.author | Yoon, H-I | - |
dc.contributor.author | Lee, C-T | - |
dc.contributor.author | Lee, J. H. | - |
dc.date.accessioned | 2012-05-29T02:11:02Z | - |
dc.date.available | 2012-05-29T02:11:02Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | CANCER GENE THERAPY; Vol.17 5; 356-364 | ko_KR |
dc.identifier.issn | 0929-1903 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76519 | - |
dc.description.abstract | Genetic immunotherapy is considered an ideal treatment modality for cancer because of its systemic nature. This study was designed to develop a potent novel genetic immunotherapy by combining conditionally replicating adenovirus (CRAd) and replication-defective adenovirus expressing interferon-beta (ad-IFN-beta). We investigated the efficacy of this therapy in an immunocompetent mouse tumor model. Transduction with CRAd (Delta 24RGD) induced cytolysis in a mouse lung cancer cell line (Lewis lung carcinoma (LLC)). Combined transduction of ad-IFN-beta and Delta 24RGD in the LLC cells induced a greater and more prolonged production of IFN-beta. Media transfer from the LLC-Delta 24RGD-ad-IFN-beta to untransduced LLC cells induced the production of IFN-beta; these results confirmed the replication and release of ad-IFN-beta. LLC cells transduced with ad-IFN-beta and Delta 24RGD had decreased tumorigenicity in syngeneic mice. Tumor vaccination with irradiated LLC-ad-IFN-beta-Delta 24RGD showed a significant increase in the survival of tumor-bearing syngeneic mice compared with mice with a single transduced LLC vaccination; this was mediated by an enhanced cytotoxic T-lymphocyte response against the LLC cells. The results of this study showed that cotransduced Delta 24RGD to ad-IFN-beta aided the replication of ad-IFN-beta in the LLC cells. A high local concentration of IFN-beta and local release of tumor antigen by CRAd induced strong antitumor immunity. This combination strategy might provide a powerful means by which ad-cytokines and CRAd can be combined and other adenoviruses expressing different cytokines might also be used. Cancer Gene Therapy (2010) 17, 356-364; doi:10.1038/cgt.2009.78; published online 6 November 2009 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | NATURE PUBLISHING GROUP | ko_KR |
dc.subject | conditionally replicating adenovirus | ko_KR |
dc.subject | lung cancer | ko_KR |
dc.subject | genetic immunotherapy | ko_KR |
dc.subject | adenovirus-IFN-beta | ko_KR |
dc.title | Genetic immunotherapy of lung cancer using conditionally replicating adenovirus and adenovirus-interferon-beta | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1038/cgt.2009.78 | - |
dc.citation.journaltitle | CANCER GENE THERAPY | - |
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dc.description.tc | 1 | - |
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