Publications
Detailed Information
Enhancement of Gastric Ulcer Healing and Angiogenesis by Cochinchina Momordica Seed Extract in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jung Mook | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Kim, Bongcheol | - |
dc.contributor.author | Kim, Joo-Hyon | - |
dc.contributor.author | Park, Ji Hyun | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Lee, Mi Kyoung | - |
dc.contributor.author | Lee, Bong-Yong | - |
dc.date.accessioned | 2012-05-29T02:34:37Z | - |
dc.date.available | 2012-05-29T02:34:37Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 6; 875-881 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76525 | - |
dc.description.abstract | Cochinchina momordica seed is the dried ripe seed of Momordica cochinchinensis, a perennial vine. The antiulcer effect of an extract from cochinchina momordica seeds (SK-MS10) was evaluated in a rat model of acetic acid-induced gastric ulcers. Gastric ulcers were produced by subserosal injection of acetic acid. SK-MS10 (200 mg/kg) or vehicle was administered orally once per day for 14 days after the acetic acid injection. The stomach was removed and the ulcer size measured at day 7 and 14 of the treatment. Expression of vascular endothelial growth factor (VEGF) was assessed by real-time RT-PCR and Western blot analysis. In addition, the microvasculature density (MVD) adjacent to the ulcer margin was examined by immunohistochemistry. The treatment with SK-MS10 for 7 and 14 days significantly accelerated ulcer healing and increased the expression of mRNA (at day 7) as well as VEGF protein (at day 14) compared to the vehicle-treated rats. The MVD for factor VIII was also higher in the SK-MS10 treatment group compared to the vehicle-treated rats; however, these differences were not statistically significant. These results suggest that SK-MS10 treatment accelerates the healing of gastric ulcers via upregulation of VEGF and angiogenesis in an acetic acid rat model. | ko_KR |
dc.description.sponsorship | This study was supported by grant no 06-2007-134-0
from the Seoul National University Hospital Research fund. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Cochinchina Momordica Seed Extract | ko_KR |
dc.subject | Acetic Acid | ko_KR |
dc.subject | Angiogenesis | ko_KR |
dc.subject | Vascular Endothelial Growth Factor | ko_KR |
dc.subject | Stomach Ulcer | ko_KR |
dc.title | Enhancement of Gastric Ulcer Healing and Angiogenesis by Cochinchina Momordica Seed Extract in Rats | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 강정묵 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 김봉철 | - |
dc.contributor.AlternativeAuthor | 김주현 | - |
dc.contributor.AlternativeAuthor | 이봉용 | - |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 이미경 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.3346/jkms.2010.25.6.875 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.description.citedreference | Kang JM, 2009, DIGEST DIS SCI, V54, P2549, DOI 10.1007/s10620-008-0671-6 | - |
dc.description.citedreference | Ohno T, 2008, GASTROENTEROLOGY, V134, P215, DOI 10.1053/j.gastro.2007.10.001 | - |
dc.description.citedreference | Amagase K, 2007, DIGEST DIS SCI, V52, P1879, DOI 10.1007/s10620-007-9769-5 | - |
dc.description.citedreference | Kimura Y, 2006, BRIT J PHARMACOL, V148, P860, DOI 10.1038/sj.bjp.0706794 | - |
dc.description.citedreference | Tamura K, 2006, VASC PHARMACOL, V44, P411, DOI 10.1016/j.vph.2006.02.009 | - |
dc.description.citedreference | Yeo M, 2006, GUT, V55, P26, DOI 10.1136/gut.2005.067454 | - |
dc.description.citedreference | Tarnawski AS, 2005, DIGEST DIS SCI, V50, pS24, DOI 10.1007/s10620-005-2803-6 | - |
dc.description.citedreference | Watanabe T, 2005, DIGEST DIS SCI, V50, pS63, DOI 10.1007/s10620-005-2808-1 | - |
dc.description.citedreference | Tsoi AYK, 2005, J PEPT SCI, V11, P665, DOI 10.1002/psc.666 | - |
dc.description.citedreference | Okabe S, 2005, BIOL PHARM BULL, V28, P1321 | - |
dc.description.citedreference | GAO XM, 2005, CHINESE MAT MED, P601 | - |
dc.description.citedreference | Wong RCH, 2004, PEPTIDES, V25, P163, DOI 10.1016/j.peptides.2004.01.002 | - |
dc.description.citedreference | Tsoi AYK, 2004, BIOL CHEM, V385, P185, DOI 10.1515/BC.2004.037 | - |
dc.description.citedreference | Ishida BK, 2004, J AGR FOOD CHEM, V52, P274, DOI 10.1021/jf030616i | - |
dc.description.citedreference | Harsch IA, 2003, EUR J PHARMACOL, V481, P249, DOI 10.1016/j.ejphar.2003.09.019 | - |
dc.description.citedreference | Amagase K, 2003, J PHYSIOL PHARMACOL, V54, P349 | - |
dc.description.citedreference | Guo JS, 2002, TOXICOL APPL PHARM, V183, P41, DOI 10.1006/taap.2002.9457 | - |
dc.description.citedreference | Ishihara M, 2002, EUR J PHARMACOL, V444, P209 | - |
dc.description.citedreference | Jones MK, 2001, GASTROENTEROLOGY, V121, P1040, DOI 10.1053/gast.2001.29308 | - |
dc.description.citedreference | Kim SY, 2001, J KOREAN MED SCI, V16, P579 | - |
dc.description.citedreference | Watanabe T, 2001, GUT, V48, P774 | - |
dc.description.citedreference | Gurbuz I, 2000, J ETHNOPHARMACOL, V71, P77, DOI 10.1016/S0378-8741(99)00178-6 | - |
dc.description.citedreference | Hernandez JF, 2000, BIOCHEMISTRY-US, V39, P5722 | - |
dc.description.citedreference | MA L, 2000, LIFE SCI, V66, P213 | - |
dc.description.citedreference | Huang B, 1999, INT J BIOCHEM CELL B, V31, P707 | - |
dc.description.citedreference | Szabo S, 1998, DIGEST DIS SCI, V43, p40S | - |
dc.description.citedreference | Takahashi M, 1997, BIOCHEM BIOPH RES CO, V234, P493 | - |
dc.description.citedreference | SZABO S, 1995, SCAND J GASTROENTE S, V210, P15 | - |
dc.description.citedreference | LAWSON DC, 1994, DIGEST DIS SCI, V39, P1405 | - |
dc.description.citedreference | NASH J, 1994, DRUGS, V47, P862 | - |
dc.description.citedreference | WEIDNER N, 1991, NEW ENGL J MED, V324, P1 | - |
dc.description.citedreference | JO JS, 1991, J KOREAN MED SCI, V6, P197 | - |
dc.description.citedreference | LEUNG DW, 1989, SCIENCE, V246, P1306 | - |
dc.description.citedreference | OKABE S, 1972, AM J DIG DIS, V17, P619 | - |
dc.description.citedreference | KUBOTA K, 1971, YAKUGA ZASSHI, V91, P174 | - |
dc.description.citedreference | TAKAGI K, 1969, JPN J PHARMACOL, V19, P418 | - |
dc.description.tc | 2 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.