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Peroxisome Proliferator-Activated Receptor-gamma and Its Coactivator-1 alpha Gene Polymorphisms in Korean Women with Polycystic Ovary Syndrome
DC Field | Value | Language |
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dc.contributor.author | Chae, Soo Jin | - |
dc.contributor.author | Kim, Jin Ju | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Kim, Jong Mee | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.contributor.author | Cho, Young Min | - |
dc.date.accessioned | 2012-05-29T06:18:09Z | - |
dc.date.available | 2012-05-29T06:18:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | GYNECOLOGIC AND OBSTETRIC INVESTIGATION; Vol.70 1; 1-7 | ko_KR |
dc.identifier.issn | 0378-7346 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76548 | - |
dc.description.abstract | Background/Aims: To investigate whether the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) Pro12Ala and the PPAR-gamma coactivator-1 alpha (PGC-1 alpha) Gly482Ser polymorphisms were associated with polycystic ovary syndrome (PCOS). Methods: Genetic analyses of the PPAR-gamma Pro12Ala and the PGC-1 alpha Gly482Ser polymorphisms were performed in 184 patients with PCOS and 256 controls. Hormone levels, biochemical and clinical features were analyzed according to these polymorphisms. Results: Neither the PPAR-gamma Pro12Ala nor the PGC-1 alpha Gly482Ser polymorphism showed significant differences in genotypic distribution between women with PCOS and controls. In PCOS patients, women with the non-Pro/Pro genotypes of the PPAR-gamma Pro12Ala polymorphism showed statistically significantly higher HDL levels than those with the Pro/Pro genotype (p = 0.002). PCOS patients who had the Ser/Ser genotype of the PGC-1 alpha Gly482Ser polymorphism had significantly higher levels of postprandial 2-hour insulin than those with the Gly/Ser genotype (p = 0.045). Conclusions: Neither the PPAR-gamma Pro12Ala nor the P GC-1 alpha Gly482Ser polymorphism were supposed to be susceptible genes in PCOS. However, in PCOS patients, the PPAR-gamma Pro12Ala and the PGC-1 alpha Gly482Ser polymorphism may modulate the concentrations of serum HDL levels and postprandial 2-hour insulin level, respectively. Copyright (C) 2010 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Peroxisome proliferator-activated receptor-gamma | ko_KR |
dc.subject | PPAR-gamma coactivator-1 alpha | ko_KR |
dc.subject | Polycystic ovary syndrome | ko_KR |
dc.title | Peroxisome Proliferator-Activated Receptor-gamma and Its Coactivator-1 alpha Gene Polymorphisms in Korean Women with Polycystic Ovary Syndrome | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 채수진 | - |
dc.contributor.AlternativeAuthor | 김진주 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 김종미 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1159/000279309 | - |
dc.citation.journaltitle | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | - |
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