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The Correlation of Endoscopic and Histological Diagnosis of Gastric Atrophy

Cited 40 time in Web of Science Cited 47 time in Scopus
Authors
Eshmuratov, Alisher; Nah, Jong Chun; Kim, Nayoung; Lee, Hye Seung; Lee, Byoung Hwan; Park, Young Soo; Jung, Hyun Chae; Song, In Sung; Lee, Dong Ho; Uhm, Min Sik; Lee, Hee Eun
Issue Date
2010-05
Publisher
SPRINGER
Citation
DIGESTIVE DISEASES AND SCIENCES; Vol.55 5; 1364-1375
Keywords
StomachAtrophyHistologyEndoscopy
Abstract
Gastric atrophy is a premalignant condition. The aim of this study was to evaluate the correlation between histological and endoscopic findings of atrophy, and to analyze the affecting factors. Atrophy was graded by endoscopy, and biopsy was performed in the antrum and body for the diagnosis of atrophy according to the Sydney system in the 1,330 subjects. Both endoscopic and histological atrophy increased in proportion to age (P < 0.001). The prevalence of endoscopic atrophy was significantly lower than that of histological atrophy especially below 50 years of age. The sensitivity and specificity of endoscopy for the diagnosis of atrophy based on histological diagnosis of atrophy were 61.5 and 57.7% in the antrum, and were 46.8 and 76.4% in the body of the stomach. Multivariate analysis showed that an age < 50 (OR 0.38, 95% CI 0.25-0.61) and a PG I/II ratio > 3 (OR 0.50, 95% CI 0.35-0.71) in the antrum, and an age < 50 (OR 0.43, 95% CI 0.19-1.00) and a CRP > 5 mg/dl (OR 0.53, 95% CI 0.30-0.94) decreased the sensitivity of the endoscopic diagnosis of atrophy in the body. A high index of suspicion of gastric atrophy is important in the young age group, and confirmation of the diagnosis by histology is necessary.
ISSN
0163-2116
Language
English
URI
http://hdl.handle.net/10371/76550
DOI
https://doi.org/10.1007/s10620-009-0891-4
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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