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A Relationship Between Alzheimer`s Disease and Type 2 Diabetes Mellitus Through the Measurement of Serum Amyloid-beta Autoantibodies
DC Field | Value | Language |
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dc.contributor.author | Kim, Insub | - |
dc.contributor.author | Lee, Junhee | - |
dc.contributor.author | Hong, Hyun Joo | - |
dc.contributor.author | Jung, Eun Sun | - |
dc.contributor.author | Jeong, In Kyong | - |
dc.contributor.author | So, Insuk | - |
dc.contributor.author | Mook-Jung, Inhee | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Ku, Yun Hyi | - |
dc.date.accessioned | 2012-05-29T08:50:11Z | - |
dc.date.available | 2012-05-29T08:50:11Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | JOURNAL OF ALZHEIMERS DISEASE; Vol.19 4; 1371-1376 | ko_KR |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76575 | - |
dc.description.abstract | Increasing evidence suggests that type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer`s disease (AD). To examine the relationship between T2DM and AD, autoantibodies against amyloid-A beta were measured in the serum of T2DM patients and age-matched controls. Levels of A beta autoantibody were measured by ELISA in serum samples of T2DM patients (n = 92) and age-matched control group (n = 106). A beta autoantibody levels were increased in T2DM compared with age-matched controls by 45.4 +/- 8.1% (p < 0.001). Females had higher A beta autoantibody levels than males in both T2DM and control group. A beta autoantibody levels in the T2DM group were positively correlated with the levels of cholesterol (p = 0.011), low density lipoprotein cholesterol (p = 0.020), and triglycerides (p = 0.039). In conclusion, the level of A beta autoantibody is dramatically elevated in patient serum of T2DM, and, as such, might be used as a possible biomarker for T2DM. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | IOS PRESS | ko_KR |
dc.subject | A beta Autoantibody | ko_KR |
dc.subject | type 2 diabetes mellitus | ko_KR |
dc.subject | cholesterol | ko_KR |
dc.subject | biomarker | ko_KR |
dc.subject | Alzheimer`s disease | ko_KR |
dc.title | A Relationship Between Alzheimer`s Disease and Type 2 Diabetes Mellitus Through the Measurement of Serum Amyloid-beta Autoantibodies | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김인섭 | - |
dc.contributor.AlternativeAuthor | 이준희 | - |
dc.contributor.AlternativeAuthor | 홍현주 | - |
dc.contributor.AlternativeAuthor | 정은선 | - |
dc.contributor.AlternativeAuthor | 구윤희 | - |
dc.contributor.AlternativeAuthor | 정인경 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 소인석 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.3233/JAD-2010-1332 | - |
dc.citation.journaltitle | JOURNAL OF ALZHEIMERS DISEASE | - |
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dc.description.tc | 0 | - |
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