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Syndecan-2 Functions as a Docking Receptor for Pro-matrix Metalloproteinase-7 in Human Colon Cancer Cells

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dc.contributor.authorRyu, Heui-Young-
dc.contributor.authorLee, Jiseon-
dc.contributor.authorYang, Sanghwa-
dc.contributor.authorPark, Haein-
dc.contributor.authorJung, Kyeong-Cheon-
dc.contributor.authorSeong, Je-Kyung-
dc.contributor.authorOh, Eok-Soo-
dc.contributor.authorHan, Inn-Oc-
dc.contributor.authorLee, Seung-Taek-
dc.contributor.authorChoi, Sojoong-
dc.date.accessioned2012-05-30T02:41:16Z-
dc.date.available2012-05-30T02:41:16Z-
dc.date.issued2009-12-18-
dc.identifier.citationJOURNAL OF BIOLOGICAL CHEMISTRY; Vol.284 51; 35692-35701ko_KR
dc.identifier.issn0021-9258-
dc.identifier.urihttps://hdl.handle.net/10371/76614-
dc.description.abstractAlthough elevated syndecan-2 expression is known to be crucial for the tumorigenic activity in colon carcinoma cells, how syndecan-2 regulates colon cancer is unclear. In human colon adenocarcinoma tissue samples, we found that both mRNA and protein expression of syndecan-2 were increased, compared with the neighboring normal epithelium, suggesting that syndecan-2 plays functional roles in human colon cancer cells. Consistent with this notion, syndecan-2-overexpressing HT-29 colon adenocarcinoma cells showed enhanced migration/invasion, anchorage-independent growth, and primary tumor formation in nude mice, paralleling their morphological changes into highly tumorigenic cells. In addition, our experiments revealed that syndecan-2 enhanced both expression and secretion of matrix metalloproteinase-7 (MMP-7), directly interacted with pro-MMP-7, and potentiated the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Collectively, these data strongly suggest that syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells.ko_KR
dc.description.sponsorshipThis work was supported by a grant of the National R&D Program for Cancer
Control, Ministry of Health & Welfare, Republic of Korea (Grant 0420070-1
to E. S. O.) and a grant of the Korea Healthcare Technology R&D Projects,
Ministry for Health, Welfare, and Family Affairs, Republic of Korea (Grant
A090165).		ko_KR
dc.language.isoenko_KR
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INCko_KR
dc.titleSyndecan-2 Functions as a Docking Receptor for Pro-matrix Metalloproteinase-7 in Human Colon Cancer Cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor류희영-
dc.contributor.AlternativeAuthor이지선-
dc.contributor.AlternativeAuthor양상화-
dc.contributor.AlternativeAuthor박해인-
dc.contributor.AlternativeAuthor최소중-
dc.contributor.AlternativeAuthor정경천-
dc.contributor.AlternativeAuthor이승택-
dc.contributor.AlternativeAuthor성제경-
dc.contributor.AlternativeAuthor한인옥-
dc.contributor.AlternativeAuthor오억수-
dc.identifier.doi10.1074/jbc.M109.054254-
dc.citation.journaltitleJOURNAL OF BIOLOGICAL CHEMISTRY-
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