Benefits of biocompatible PD fluid for preservation of residual renal function in incident CAPD patients: a 1-year study

Abstract

Methods. Ninety-one incident patients started CAPD for 12-month treatment with either LF (Balance (R), Fresenius, n = 48) or CF (CAPD/DPCA (R), Fresenius, n = 43). RRF, peritoneal solute transport rate and solute clearance were measured every 6 months. Results. LF had a significant effect on the change of glomerular filtration rate (GFR) (P = 0.048 by the mixed model). In per-protocol analysis, GFR in the LF group did not decrease over a 12-month period, while GFR in the control group significantly decreased (0.13 +/- 33.4 L/ week/1.73 m(2) for LF versus -13.6 +/- 19.4 L/week/1.73 m(2) for CF, P = 0.049). Subgroup analysis for patients with initial GFR of 2 mL/min/1.73 m(2) or above showed a significantly higher GFR for the LF group over the 12-month period. At Month 13, serum total CO(2) levels were higher and serum albumin levels were lower in the LF group. No differences between the two groups were observed for the C-reactive protein. Over the 12-month period, effluent cancer antigen-125 levels significantly increased in the LF group, compared with those of the CF group, while effluent interleukin-6 levels were not different between the two groups. Conclusion. Our study suggests that LF may better preserve RRF over the 12-month treatment period in incident CAPD patients.