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Cerebral white matter hyperintensity is mainly associated with hypertension among the components of metabolic syndrome in Koreans

Cited 13 time in Web of Science Cited 16 time in Scopus
Authors
Choi, Hoon Sung; Cho, Young Min; Kang, Jin Hwa; Shin, Chan Soo; Lee, Hong Kyu; Park, Kyong Soo
Issue Date
2009-08
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
CLINICAL ENDOCRINOLOGY; Vol.71 2; 184-188
Abstract
P>Background Cerebral white matter hyperintensity (WMH) is a common abnormality in brain magnetic resonance imaging (MRI) and is known to be associated with ischaemic stroke. Previous studies revealed that the risk factors for cerebral WMH were age, female gender, hypertension and diabetes. In this study we examined the association between cerebral WMH and metabolic syndrome, a cluster of hypertension, glucose intolerance, abdominal obesity and dyslipidaemia. Methods and results We reviewed the results of brain MRI of 5498 subjects who underwent routine check-ups including laboratory tests at the Seoul National University Health Care System. Among the subjects who met the inclusion criteria (n = 5104), 1693 (33 center dot 2%) had cerebral WMH. They were characterized by old age, female predominance, higher body mass index (BMI), larger waist circumference, higher blood pressure, higher fasting plasma glucose level, and higher haemoglobin A1c (HbA1c). In multivariate analyses, age, female gender and hypertension were the independent risk factors for cerebral WMH. Metabolic syndrome was associated with cerebral WMH after adjusting for age and gender [odds ratio (OR) 1 center dot 20, 95% confidence interval (CI) 1 center dot 04-1 center dot 39, P = 0 center dot 014]. Among the components of metabolic syndrome, hypertension was independently associated with cerebral WMH (OR 1 center dot 20, 95% CI 1 center dot 05-1 center dot 38, P = 0 center dot 007). Conclusion Age, female gender and hypertension were risk factors for cerebral WMH in the Korean population. Cerebral WMH was also associated with metabolic syndrome; however, metabolic syndrome offered no advantage over hypertension alone in predicting cerebral WMH.
ISSN
0300-0664
Language
English
URI
https://hdl.handle.net/10371/76630
DOI
https://doi.org/10.1111/j.1365-2265.2008.03444.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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