S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
혐색소성 신세포암(Chromophobe Renal Cell Carcinoma)에서 E-cadherin 단백의 발현 양상과 임상적 의의
Expression of E-cadherin in Chromophobe Renal Cell Carcinoma and Its Prognostic Implication
- 정은정; 박혜성; 민선영; 배정모; 문경철
- Issue Date
- KOREAN SOCIETY PATHOLOGISTS
- KOREAN JOURNAL OF PATHOLOGY; Vol.43 3; 238-243
- Background: Chromophobe renal cell carcinoma is a category of renal cell carcinoma composed of histologically characteristic tumor cells. E-cadherin is an intercellular adhesion protein that has been correlated with tumor aggressiveness in many carcinomas, including clear cell renal cell carcinoma. However, the significance of an E-cadherin expression in chromophobe renal cell carcinoma is not known. Methods : We evaluated the E-cadherin expression status of 65 chromophobe renal cell carcinomas by performing immunohistochemical staining with the tissue microarray method. The percentage of positively stained tumor cells was evaluated and this was then classified into two categories: a low expression where 0 to 25% of the cells are positive, and a high expression where more than 25% of the cells are positive. Results : Among 65 cases, 11 cases (17%) showed a low expression, and 54 cases (83.0%) showed a high expression. The tumors with low expression were more likely to have a higher stage but this was not significant (p=0.056). On the survival analysis, a low E-cadherin expression was significantly associated with poor cancer-specific survival (p=0.005) and progression-free survival (p=0.003). Conclusions : The E-cadherin expression is a good prognostic marker for survival in patients with chromophobe renal cell carcinoma.