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Long-term Clinical Outcome of Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma is Comparable to That of H. pylori-positive Lymphoma

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Authors
Chung, Su Jin; Kim, Joo Sung; Kim, Hansoo; Kim, Sang Gyun; Jung, Hyun Chae; Song, In Sung; Kim, Chul Woo
Issue Date
2009-04
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
JOURNAL OF CLINICAL GASTROENTEROLOGY; Vol.43 4; 312-317
Keywords
mucosa-associated lymphoid tissue lymphomaHelicobacter pylori-negativelong-term outcometumor location
Abstract
Goals and Background: Little is still known regarding the clinical features and prognosis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma without Helicobacter pylori (H. pylori) infection. Study: From January 1996 to April 2006, a total of 185 patients with gastric MALT lymphoma were enrolled at Seoul National University Hospital. To assess the differences in clinical characteristics and long-term outcomes between H. pylori-negative (n = 29 15.7%) and H. pylori-positive (n = 156, 84.3%) cases, we compared these 2 types of lymphoma. Results: The overall median follow-up period was 39 months. There were no significant differences between the 2 groups in terms of age, macroscopic phenotype, or histologic grade. H. pylori-negative group showed male predominancy (72.4%) and higher percentage of proximal stomach location (62.1%). Although H. pylori-negative lymphomas were more frequently presented as advanced disease (stage HE or IV, 37.9%), no significant differences in both the overall complete response and overall survival rates were observed between the 2 groups. Conclusions: Our results suggest that H. pylori-negative gastric MALT lymphoma shows a favorable long-term outcome, which is comparable to that of H. pylori-positive lymphoma.
ISSN
0192-0790
Language
English
URI
http://hdl.handle.net/10371/76648
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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