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Early Motor Balance and Coordination Training Increased Synaptophysin in Subcortical Regions of the Ischemic Rat Brain

Cited 34 time in Web of Science Cited 35 time in Scopus
Authors
Seo, Han Gil; Kim, Dae-Yul; Park, Hee Won; Lee, Shi-Uk; Park, Sung-Hye
Issue Date
2010-11
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 11; 1638-1645
Keywords
StrokeSynaptophysinMotor SkillsNeuronal Plasticity
Abstract
The aim of this study was to evaluate the effect of early motor balance and coordination training on functional recovery and brain plasticity in an ischemic rat stroke model, compared with simple locomotor exercise. Adult male Sprague-Dawley rats with cortical infarcts were trained under one of four conditions: nontrained control, treadmill training, motor training on the Rota-rod, or both Rota-rod and treadmill training. All types of training were performed from post-operation day 1 to 14. Neurological and behavioral performance was evaluated by Menzies` scale, the prehensile test, and the limb placement test, at post-operation day 1, 7, and 14. Both Rota-rod and treadmill training increased the expression of synaptophysin in subcortical regions of the ischemic hemisphere including the hippocampus, dentate gyrus, and thalamus, but did not affect levels of brain-derived neurotrophic factor or tyrosin kinase receptor B. The Rota-rod training also improved Menzies` scale and limb placement test scores, whereas the simple treadmill training did neither. The control group showed significant change only in Menzies` scale score. This study suggests that early motor balance and coordination training may induce plastic changes in subcortical regions of the ischemic hemisphere after stroke accompanied with the recovery of sensorimotor performance.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/76650
DOI
https://doi.org/10.3346/jkms.2010.25.11.1638
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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